TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.92.1.4
Choline transporter-like protein 2 (Solute carrier family 44 member 2) of 706 aas and 11 or 12 TMSs. Slc44a2/HNA-3a is important for the adhesion and activation of neutrophils in veins under inflammation and when submitted to specific shears. The fact that neutrophils expressing Slc44a2/HNA-3b have a different response on von Willebrand factor (VWF) under the conditions tested could  explain the association between HNA-3b and a reduced risk for venous thrombosis (VT) in humans (Zirka et al. 2021). See also TC# 2.A.92.1.2 for another human isoform with 91% identity.

Accession Number:Q8IWA5
Protein Name:Choline transporter-like protein 2
Length:706
Molecular Weight:80124.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Choline

Cross database links:

Entrez Gene ID: 57153   
Pfam: PF04515   
KEGG: hsa:57153   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015220 F:choline transmembrane transporter activity
GO:0004871 F:signal transducer activity
GO:0043123 P:positive regulation of I-kappaB kinase/NF-kappaB cascade

References (11)

[1] “An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.”  O'Regan S.et.al.   10677542
[2] “Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss.”  Nair T.S.et.al.   14973250
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[7] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[8] “Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear.”  Kommareddi P.K.et.al.   17926100
[9] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[10] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[11] “Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2.”  Kommareddi P.K.et.al.   20665236

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MGDERPHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVFL LLAIVGYVAV GIIAWTHGDP 
61:	RKVIYPTDSR GEFCGQKGTK NENKPYLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPDRY 
121:	LTYLNARSSR DFEYYKQFCV PGFKNNKGVA EVLQDGDCPA VLIPSKPLAR RCFPAIHAYK 
181:	GVLMVGNETT YEDGHGSRKN ITDLVEGAKK ANGVLEARQL AMRIFEDYTV SWYWIIIGLV 
241:	IAMAMSLLFI ILLRFLAGIM VWVMIIMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG 
301:	FQTDFRVYLH LRQTWLAFMI ILSILEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS 
361:	LLYPLVTFFL LCLCIAYWAS TAVFLSTSNE AVYKIFDDSP CPFTAKTCNP ETFPSSNESR 
421:	QCPNARCQFA FYGGESGYHR ALLGLQIFNA FMFFWLANFV LALGQVTLAG AFASYYWALR 
481:	KPDDLPAFPL FSAFGRALRY HTGSLAFGAL ILAIVQIIRV ILEYLDQRLK AAENKFAKCL 
541:	MTCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF 
601:	LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIVGSY LIAHGFFSVY 
661:	GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN KKAAES