TCDB is operated by the Saier Lab Bioinformatics Group

2.B.59.  The Strapped Calix[4]Pyrrole (SC4P) Family

Fluoride can be a substrate of synthetic anion transporters (see TC Families 2.B.57, 2.B.58 and this family). Clarke et al. 2016 reported the direct measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calix[4]pyrroles and showed that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the interference of naturally occurring fatty acids with the transport process and Cl- over H+/OH- transport selectivity (Clarke et al. 2016).

References associated with 2.B.59 family:

Clarke, H.J., E.N. Howe, X. Wu, F. Sommer, M. Yano, M.E. Light, S. Kubik, and P.A. Gale. (2016). Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies. J. Am. Chem. Soc. 138: 16515-16522. 27998094