2.B.59. The Strapped CalixPyrrole (SC4P) Family
Fluoride can be a substrate of synthetic anion transporters (see TC Families 2.B.57, 2.B.58 and this family). Clarke et al. 2016 reported the direct measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calixpyrroles and showed that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the interference of naturally occurring fatty acids with the transport process and Cl- over H+/OH- transport selectivity (Clarke et al. 2016).