TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.D.1.1.1









Oxysterol binding protein-related, Orp5 of 879 aas and 1 C-terminal TMS. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (Du et al. 2011). Binds 25-hydroxycholesterol and cholesterol (Suchanek et al. 2007).  Catalyzes phosphatidyl-inositol-4-P (PI4P)/phosphatidyl serine (PS) exchange between the ER and the PM (Chung et al. 2015).

Eukaryota
Metazoa
Orp5 of Homo sapiens
2.D.1.1.2









Oxysterol binding protein-related, Orp8 protein of 889 aas and 1 C-terminal TMS in the ER membrane. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (Du et al. 2011). Binds 25-hydroxycholesterol and cholesterol (Suchanek et al. 2007).  Catalyzes phosphatidyl-inositol-4-P (PI4P)/phosphatidyl serine (PS) exchange between the ER and the PM (Chung et al. 2015).

Eukaryota
Metazoa
Orp8 of Homo sapiens
2.D.1.1.3









Oxysterol binding protein of 448 aas with an N-terminal moderately hydrophobin sterol binding PH domain, Osh6.  Mediates phosphatidyl serine/phosphatidyl inositol 4-P exchange between the PM and ER (Moser von Filseck et al. 2015).

Eukaryota
Fungi
Osh6 of Saccharomyces cerevisiae
2.D.1.1.4









Oxysterol binding protein of 437 aas and 1 C-terminal TMS, Osh7, with a moderately hydrophobic N-terminal sterol binding PH domain.  Mediates phosphatidyl serine/phsophatidyl inositol 4-P exchange between the PM and ER (Moser von Filseck et al. 2015).

Eukaryota
Fungi
Osh7 of Saccharomyces cereviseae
2.D.1.1.5









Plant Orp4A protein of 386 aas and 0 TMSs.

Eukaryota
Viridiplantae
Orp4A of Arabidopsis thaliana
2.D.1.1.6









Oxysterol binding-like 3 protein of 983 aas. 

Eukaryota
Fungi
Oxysterol binding protein of Fusarium oxysporum f. sp. cubense (Panama disease fungus)
2.D.1.1.7









Oxysterol bindiing protein of 432 aas.

Eukaryota
Longamoebia
Oxysterol binding protein of Acanthamoeba castellanii
2.D.1.1.8









Uncharacterized protein of 881 aas.

Eukaryota
Intramacronucleata
UP of Paramecium tetraurelia
2.D.1.1.9









Oxysterol binding protein of 784 aas.

Eukaryota
Metazoa
Oxysterol binding protein of Drosophila melanogaster
2.D.1.1.10









Oxysterol binding protein of 405 aas.

Oxysterol BP of Plutella xylostella (Diamondback moth) (Plutella maculipennis)