TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.D.1.1.1









Oxysterol binding protein-related, Orp5 of 879 aas and 1 C-terminal TMS. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (Du et al. 2011). Binds 25-hydroxycholesterol and cholesterol (Suchanek et al. 2007).  Catalyzes phosphatidyl-inositol-4-P (PI4P)/phosphatidyl serine (PS) exchange between the ER and the PM (Chung et al. 2015). ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress (Wu et al. 2023). It may therefore be a ER stress chaparone.

Eukaryota
Metazoa, Chordata
Orp5 of Homo sapiens
2.D.1.1.2









Oxysterol binding protein-related, Orp8 protein of 889 aas and 1 C-terminal TMS in the ER membrane. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (Du et al. 2011). Binds 25-hydroxycholesterol and cholesterol (Suchanek et al. 2007).  Catalyzes phosphatidyl-inositol-4-P (PI4P)/phosphatidyl serine (PS) exchange between the ER and the PM (Chung et al. 2015).

Eukaryota
Metazoa, Chordata
Orp8 of Homo sapiens
2.D.1.1.3









Oxysterol binding protein of 448 aas with an N-terminal moderately hydrophobin sterol binding PH domain, Osh6.  Mediates phosphatidyl serine/phosphatidyl inositol 4-P exchange between the PM and ER (Moser von Filseck et al. 2015).

Eukaryota
Fungi, Ascomycota
Osh6 of Saccharomyces cerevisiae
2.D.1.1.4









Oxysterol binding protein of 437 aas and 1 C-terminal TMS, Osh7, with a moderately hydrophobic N-terminal sterol binding PH domain.  Mediates phosphatidyl serine/phsophatidyl inositol 4-P exchange between the PM and ER (Moser von Filseck et al. 2015).

Eukaryota
Fungi, Ascomycota
Osh7 of Saccharomyces cereviseae
2.D.1.1.5









Plant Orp4A protein of 386 aas and 0 TMSs.

Eukaryota
Viridiplantae, Streptophyta
Orp4A of Arabidopsis thaliana
2.D.1.1.6









Oxysterol binding-like 3 protein of 983 aas. 

Eukaryota
Fungi, Ascomycota
Oxysterol binding protein of Fusarium oxysporum f. sp. cubense (Panama disease fungus)
2.D.1.1.7









Oxysterol bindiing protein of 432 aas.

Eukaryota
Discosea
Oxysterol binding protein of Acanthamoeba castellanii
2.D.1.1.8









Uncharacterized protein of 881 aas.

Eukaryota
Ciliophora
UP of Paramecium tetraurelia
2.D.1.1.9









Oxysterol binding protein of 784 aas.

Eukaryota
Metazoa, Arthropoda
Oxysterol binding protein of Drosophila melanogaster
2.D.1.1.10









Ceramide transfer protein, CERT1, of 624 aas and possibly one TMS at residue position 250. Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are associated with intellectual disability. Gehin et al. 2023 characterized missense variants in CERT1, without which sphingolipid production goes unchecked. The clinical severity reflects the degree to which CERT autoregulation is disrupted, and inhibiting CERT pharmacologically corrects morphological and motor abnormalities in a Drosophila model of the disease (CerTra syndrome). Thus, CERT autoregulates the controls of the sphingolipid biosynthetic flux and provides insight into the structural organisation of CERT (Gehin et al. 2023).

Eukaryota
Metazoa, Chordata
CERT1 of Homo sapiens