3.A.1.110.13
Protein export system, PrtD of 564 aas and 6 TMSs. The 3.15 Å structure has been solved (Morgan et al. 2017). The structure suggests a substrate entry window just above the transporter's nucleotide binding domains. Highly kinked transmembrane helices, which frame a narrow channel, not observed in canonical peptide transporters, are likely involved in substrate translocation. The PrtD structure supports a polypeptide transport mechanism distinct from alternating access (Morgan et al. 2017).
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| Accession Number: | O67184 |
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| Protein Name: | ABC transporter (HlyB subfamily) |
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| Length: | 564 |
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| Molecular Weight: | 63100.00 |
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| Species: | Aquifex aeolicus (strain VF5) [224324] |
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| Number of TMSs: | 5 |
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| Substrate |
protein polypeptide chain |
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1: MATKENTENV LRSYLAKYKK TLIIVGLFSL FINILFLLPS IYMLAVYDIV VPSTSVPTLL
61: VITALAVVLY FALGLLQSVR AKVMQIISLK LDSELNKEVF TSSFEYAIRN PSKASAQPIN
121: DLYQLKQFLT SPVLFAIFDL PWVPIYFGVL FVFHVYYGVM AILSMAVIVA LAILNEYITK
181: KKLKESNELL VRSTNFLNRA LLNAEVVEAL GMRNNLYKKW MNFYSKHLSA FEEATDRNNF
241: LSNLTRIFRI MAQSLMLGLG GYLAIKHEIT TGMIVAGSIL LGRILGPIDT IVNGWRQIGN
301: TKVAYTRLNE FLKFLRFKRE VSVKLPEPKG EIELSNVVVV PPEGKTPVLR NINMRILPGE
361: FVAIIGPSGS GKSSLVRTIL GIWLPVHGTV EIDGADLKQW DRDYFGKFVG YLPQDIELFE
421: GTVAENIARF GELDSEKIIE AAKLSGAHDV IIKLPDGYDT YIGPGGITLS GGQRQRIALA
481: RALYGNPRIV ILDEPDSNLD EQGEQALYNA LIELKKRKVT TIIVSHRIRL LNLVDKIAIM
541: QDGTLKAFGK ADIIIQKLLR KNVN