3.A.1.121.6
MsrD of 487 aas and 0 TMSs. Involved in macrolide resistance (Zhang et al. 2016). Two ATPase domains are present in tandem. A membrane constituent is not known. Iannelli et al. 2018 suggested that MefA (TC# 2.a.1.21.1) can function with MsrD, and therefore that this MFS exporter can function as an ABC drug exporter. However,
the data presented seem inconsistent with this suggestion. Nevertheless, the two genes
encoding these two proteins are adjacent to each other, suggesting that
they may somehow function together (Iannelli et al. 2018).
|
| Accession Number: | Q65AB2 |
|---|
| Protein Name: | ABC-transporter |
|---|
| Length: | 487 |
|---|
| Molecular Weight: | 54804.00 |
|---|
| Species: | Streptococcus pyogenes [1314] |
|---|
| Number of TMSs: | 2 |
|---|
| Substrate |
|
|---|
1: MELILKAKDI RVEFKGHDVL DINELEVYDY DRIGLVGANG AGKSTLFKVL LGELIPPGCK
61: MNHLGELAYI PQLDEVTLQE EKDFALVGKL GVEQLNIQTM SGGEETRLKI AQALSAQVHG
121: ILADEPTSHL DREGIDFLIG QLKYFTGALL VISHDRYFLD EIVDKIWELK DGKITEYWGN
181: YSDYLRQKEE ERKRQAAEYE QFIAERARLE RAAEEKRKQA RKIEQKAKGS SKKKSTEGGG
241: RLAHQKSIGS KEKKMHNAAK SLENRIAALG KVEAPEGIRR IRFRQSKALE LHNPYPIVGA
301: EINKVFGDKA LFENASFQIP LGAKVALTGG NGTGKTTLIQ MILNHEEGIS ISPKAKIGYF
361: AQNGYKYNSN QNVMEFMQKD CDYNISEIRS VLASMGFKQN DIGKSLSVLS GGEIIKLLLA
421: KMLMGRYNIL IMDEPSNFLD IPSLEALEIL MKEYTGTIVF ITHDKRLLEN VADVVYEIRD
481: KKIKLKH