3.A.1.140.8
FtsEX of Bacillus subtilis where FtsE is an ATPase of 228 aas (O34814) and FtsX is a dimeric membrane protein of 296 aas and 4 TMSs in a 1 + 3 TMS arrangement (O34876). It is an ABC transporter secondarily involved in sporulation. It was initially thought to act as an importer and/or exporter,
possibly at the top of a hierarchical cascade leading to the correct
temporal initiation of sporulation, upstream of the histidine
kinases KinA, KinB and KinC, the RapA phosphatase and the Spo0A
sporulation protein (Garti-Levi et al. 2008). However, it may be involved in peptidoglycan (cell wall) remodeling together with the autolysin CwlO for which it is an activator (Rismondo and Schulz 2021).
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| Accession Number: | O34814 |
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| Protein Name: | Cell division ATP-binding protein FtsE |
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| Length: | 228 |
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| Molecular Weight: | 25620.00 |
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| Species: | Bacillus subtilis (strain 168) [224308] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Peripheral membrane protein2 |
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| Substrate |
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1: MIEMKEVYKA YPNGVKALNG ISVTIHPGEF VYVVGPSGAG KSTFIKMIYR EEKPTKGQIL
61: INHKDLATIK EKEIPFVRRK IGVVFQDFKL LPKLTVFENV AFALEVIGEQ PSVIKKRVLE
121: VLDLVQLKHK ARQFPDQLSG GEQQRVSIAR SIVNNPDVVI ADEPTGNLDP DTSWEVMKTL
181: EEINNRGTTV VMATHNKEIV NTMKKRVIAI EDGIIVRDES RGEYGSYD