3.A.1.201.16
MDR efflux pump, ABCB4a. Exports canonical MDR susbtrates such as
calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).
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| Accession Number: | I0DHH7 |
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| Protein Name: | ATP-binding cassette transporter subfamily B member 4a |
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| Length: | 1298 |
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| Molecular Weight: | 141531.00 |
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| Species: | Strongylocentrotus purpuratus (Purple sea urchin) [7668] |
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| Number of TMSs: | 12 |
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| Substrate |
mitoxantrone |
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1: MVVENGHTKG LDDDGTEVAF KNGNYGATNG KDTANGTIKG EEKSDEKENE KEEEKPQVPF
61: TRLFRYATGL DGLFMFIGCF AAVCHGCAWP ALNIVFGGLI DEFVDFDKLN TTNTTDFTAT
121: LPPGLDPAKE FDNQMQMYAV IFTYIGIGVM VMAYLQSSMW TLAGERQIYK IRQAFFNAIL
181: HQEIQWFDVH KSGELTSRLA DDMERVKDGL GDKIALCLQS LSLFLAGFGI AFWKSWELTL
241: VLLSTTPLLA AAGGFMAYFL TSFAKLEQES YAQAGSVAEE VLSCVRTVIA FGGEQKEVTR
301: YEKELKEARD VGVKKGVTSG VGMGITMFIM FGSYALAFWY GPKLVADGRI TGGDVMIVFF
361: SVMIGSFSIG NISPSMTAIT AARGAAVTLF DVIDARPAID TRSKKGIVPA EMTGNIDFQG
421: VEFSYPTRDD VPVLKGVDLS IRKGQTVALV GSSGCGKSTT INLLLRFYEK LGGNILIDGH
481: KIEELNLHWL RRHMGVVSQE PVLFNCSIET NISYGRDGVT KEEIINAAKM ANAHDFISKL
541: PKGYDTMVGE RGAQLSGGQK QRVAIARALV RNPPILLLDE ATSALDRESE KVVQQALDKA
601: SEGRTTLVIA HRLTTIRNAD VIYAFEDGRV VEFGDHAELM KRDGVYKQLV TLQTLDGAGE
661: ESTSSSKEVV RKESIKRLPS RQMSRQISRQ MSNGSGKMEE SVEVKEEVEE EEVEERGYLE
721: ILKMNKPEWL YIVVGCVFAG ILGVAMPAFA ILFSEVIAIF SLPADELREE SVFWALMFLA
781: LGGAFFVSNS VTGYCFSISG EELTLRLRKK AFWTILRQDC AYFDQPSHST GALATRLSSD
841: ASNVKGATGM RISTIVQAIV TMVVAITIGF VFGWKLALLI FGCLPVLALS GALEMKILQG
901: GHEKDAALIE EAGKIAAEAI ENVRTVASLN LEDRMIANYT EQLQNPYRQG KINSQINGLA
961: FAVSQAMIFF IYAASFRLGG YLVSIGDMTV DEVFKVVFGV AFAGISVGQS LAFLPDYAKA
1021: RHSADLMLHL FSIKPLIDNY STDGAQPQKV DGKIEYSGLK FSYPTRPDVT VLKGLSLTIK
1081: PGQTVALVGE SGCGKSTLVS LLERFYDPAQ GSVALDGTPV KDINIQWLRA NMAIVSQEPI
1141: LFACSIGDNI QYGVETPMEQ AAIENVAKMA NIHDFIASLP LGYDTLVGEK GAQLSGGQKQ
1201: RVAIARAMAR NPRILLLDEA TSALDTESEK VVQAALDNAM QGRTSIVIAH RLSTIQNADT
1261: IAVIREGVVV ESGSHQELLQ SKGHYFTLTG GKIDVESE