3.A.1.201.18
Leptomycin B resistance protein 1, Pmd1, of 1362 aas and 13 predicted TMSs (Nishi et al. 1992). This protein is similar in sequence to Ste6-2b of Pichia pastoralis the structure of which has been solved by cryoEM. It transports rodamines 6G and 123, Dvarapamil, flconazole, and itraconazole, and it's ATPase activity is inhibited by terbinafine, niftifine, ketoconazole and asmorilfine, It also appears to interact with sterols (Schleker et al. 2022).
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| Accession Number: | P36619 |
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| Protein Name: | Leptomycin B resistance protein pmd1 |
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| Length: | 1362 |
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| Molecular Weight: | 149632.00 |
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| Species: | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSLHSKKSTS TVKDNEHSLD LSIKSIPSNE KNFSTEKSEN EASESHVVDV VKDPFEQYTP
61: EEQEILYKQI NDTPAKLSGY PRILSYADKW DIMLQLAGTI TGIGAGLGMP LMSLVSGQLA
121: QAFTDLASGK GASSFQHTVD HFCLYFIYIA IGVFGCSYIY TVTFIIAGER IARRIRQDYL
181: HAILSQNIGY FDRLGAGEIT TRITTDTNFI QDGLGEKVGL VFFAIATFVS GFVIAFIRHW
241: KFTLILSSMF PAICGGIGLG VPFITKNTKG QIAVVAESST FVEEVFSNIR NAFAFGTQDI
301: LAKLYNKYLI TAQRFGINKA IAMGLMVGWM FFVAYGVYGL AFWEGGRLLH AGDLDVSKLI
361: GCFFAVLIAS YSLANISPKM QSFVSCASAA KKIFDTIDRV SPINAFTPTG DVVKDIKGEI
421: ELKNIRFVYP TRPEVLVLDN FSLVCPSGKI TALVGASGSG KSTIIGLVER FYDPIGGQVF
481: LDGKDLRTLN VASLRNQISL VQQEPVLFAT TVFENITYGL PDTIKGTLSK EELERRVYDA
541: AKLANAYDFI MTLPEQFSTN VGQRGFLMSG GQKQRIAIAR AVISDPKILL LDEATSALDS
601: KSEVLVQKAL DNASRSRTTI VIAHRLSTIR NADNIVVVNA GKIVEQGSHN ELLDLNGAYA
661: RLVEAQKLSG GEKDQEMVEE ELEDAPREIP ITSFGDDDED NDMASLEAPM MSHNTDTDTL
721: NNKLNEKDNV VFEDKTLQHV ASEIVPNLPP ADVGELNEEP KKSKKSKKNN HEINSLTALW
781: FIHSFVRTMI EIICLLIGIL ASMICGAAYP VQAAVFARFL NIFTDLSSTD FLHKVNVFAV
841: YWLILAIVQF FAYAISNFAM TYAMEAVLQR IRYHLFRTLL RQDVEFFDRS ENTVGAITTS
901: LSTKIQSLEG LSGPTLGTFF QILTNIISVT ILSLATGWKL GLVTLSTSPV IITAGYYRVR
961: ALDQVQEKLS AAYKESAAFA CESTSAIRTV ASLNREENVF AEYCDSLIKP GRESAIASLK
1021: SGLFFSAAQG VTFLINALTF WYGSTLMRKG EYNIVQFYTC FIAIVFGIQQ AGQFFGYSAD
1081: VTKAKAAAGE IKYLSESKPK IDTWSTEGKK VESLQSAAIE FRQVEFSYPT RRHIKVLRGL
1141: NLTVKPGQFV AFVGSSGCGK STTIGLIERF YDCDNGAVLV DGVNVRDYNI NDYRKQIALV
1201: SQEPTLYQGT VRENIVLGAS KDVSEEEMIE ACKKANIHEF ILGLPNGYNT LCGQKGSSLS
1261: GGQKQRIAIA RALIRNPKIL LLDEATSALD SHSEKVVQEA LNAASQGRTT VAIAHRLSSI
1321: QDADCIFVFD GGVIAEAGTH AELVKQRGRY YELVVEQGLN KA