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3.A.1.201.18
Leptomycin B resistance protein 1, Pmd1, of 1362 aas and 13 predicted TMSs (Nishi et al. 1992). This protein is similar in sequence to Ste6-2b  of Pichia pastoralis the structure of which has been solved by cryoEM. It transports rodamines 6G and 123, Dvarapamil, flconazole, and itraconazole, and it's ATPase activity is inhibited by terbinafine, niftifine, ketoconazole and asmorilfine, It also appears to interact with sterols (Schleker et al. 2022).

Accession Number:P36619
Protein Name:Leptomycin B resistance protein pmd1
Length:1362
Molecular Weight:149632.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLHSKKSTS TVKDNEHSLD LSIKSIPSNE KNFSTEKSEN EASESHVVDV VKDPFEQYTP 
61:	EEQEILYKQI NDTPAKLSGY PRILSYADKW DIMLQLAGTI TGIGAGLGMP LMSLVSGQLA 
121:	QAFTDLASGK GASSFQHTVD HFCLYFIYIA IGVFGCSYIY TVTFIIAGER IARRIRQDYL 
181:	HAILSQNIGY FDRLGAGEIT TRITTDTNFI QDGLGEKVGL VFFAIATFVS GFVIAFIRHW 
241:	KFTLILSSMF PAICGGIGLG VPFITKNTKG QIAVVAESST FVEEVFSNIR NAFAFGTQDI 
301:	LAKLYNKYLI TAQRFGINKA IAMGLMVGWM FFVAYGVYGL AFWEGGRLLH AGDLDVSKLI 
361:	GCFFAVLIAS YSLANISPKM QSFVSCASAA KKIFDTIDRV SPINAFTPTG DVVKDIKGEI 
421:	ELKNIRFVYP TRPEVLVLDN FSLVCPSGKI TALVGASGSG KSTIIGLVER FYDPIGGQVF 
481:	LDGKDLRTLN VASLRNQISL VQQEPVLFAT TVFENITYGL PDTIKGTLSK EELERRVYDA 
541:	AKLANAYDFI MTLPEQFSTN VGQRGFLMSG GQKQRIAIAR AVISDPKILL LDEATSALDS 
601:	KSEVLVQKAL DNASRSRTTI VIAHRLSTIR NADNIVVVNA GKIVEQGSHN ELLDLNGAYA 
661:	RLVEAQKLSG GEKDQEMVEE ELEDAPREIP ITSFGDDDED NDMASLEAPM MSHNTDTDTL 
721:	NNKLNEKDNV VFEDKTLQHV ASEIVPNLPP ADVGELNEEP KKSKKSKKNN HEINSLTALW 
781:	FIHSFVRTMI EIICLLIGIL ASMICGAAYP VQAAVFARFL NIFTDLSSTD FLHKVNVFAV 
841:	YWLILAIVQF FAYAISNFAM TYAMEAVLQR IRYHLFRTLL RQDVEFFDRS ENTVGAITTS 
901:	LSTKIQSLEG LSGPTLGTFF QILTNIISVT ILSLATGWKL GLVTLSTSPV IITAGYYRVR 
961:	ALDQVQEKLS AAYKESAAFA CESTSAIRTV ASLNREENVF AEYCDSLIKP GRESAIASLK 
1021:	SGLFFSAAQG VTFLINALTF WYGSTLMRKG EYNIVQFYTC FIAIVFGIQQ AGQFFGYSAD 
1081:	VTKAKAAAGE IKYLSESKPK IDTWSTEGKK VESLQSAAIE FRQVEFSYPT RRHIKVLRGL 
1141:	NLTVKPGQFV AFVGSSGCGK STTIGLIERF YDCDNGAVLV DGVNVRDYNI NDYRKQIALV 
1201:	SQEPTLYQGT VRENIVLGAS KDVSEEEMIE ACKKANIHEF ILGLPNGYNT LCGQKGSSLS 
1261:	GGQKQRIAIA RALIRNPKIL LLDEATSALD SHSEKVVQEA LNAASQGRTT VAIAHRLSSI 
1321:	QDADCIFVFD GGVIAEAGTH AELVKQRGRY YELVVEQGLN KA