3.A.1.201.24
Multidrug exporter, MDR49 or Pgp of 1302 aas and 12 TMSs. Exports many drugs as well as pollutants such as polycyclic aromatic hydrocarbons (PAHs) which are major sources of air, water and soil pollution. MDR49 is expressed at all developmental stages of the life cycle and in many tissues (Vache et al. 2007). It is essential for early development, probably because Drosophila germ cell migration depends on lipid-modified peptides that are secreted by MDR49 (Ricardo and Lehmann 2009).
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| Accession Number: | Q00449 |
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| Protein Name: | Multidrug resistance protein homolog 49 |
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| Length: | 1302 |
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| Molecular Weight: | 142739.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
polycyclic arene, drug |
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1: MVKKEESRLP QAGDFQLKEG SVVDATRKYS YFDLFRYSTR CERFLLVVSL LVATAASAFI
61: PYFMIIYGEF TSLLVDRTVG VGTSSPAFAL PMFGGGQQLT NASKEENNQA IIDDATAFGI
121: GSLVGSVAMF LLITLAIDLA NRIALNQIDR IRKLFLEAML RQDIAWYDTS SGSNFASKMT
181: EDLDKLKEGI GEKIVIVVFL IMTFVIGIVS AFVYGWKLTL VVLSCVPFII AATSVVARLQ
241: GSLAEKELKS YSDAANVVEE VFSGIRTVFA FSGQEKEKER FGKLLIPAEN TGRKKGLYSG
301: MGNALSWLII YLCMALAIWY GVTLILDERD LPDRVYTPAV LVIVLFAVIM GAQNLGFASP
361: HVEAIAVATA AGQTLFNIID RPSQVDPMDE KGNRPENTAG HIRFEGIRFR YPARPDVEIL
421: KGLTVDVLPG QTVAFVGASG CGKSTLIQLM QRFYDPEAGS VKLDGRDLRT LNVGWLRSQI
481: GVVGQEPVLF ATTIGENIRY GRPSATQADI EKAARAANCH DFITRLPKGY DTQVGEKGAQ
541: ISGGQKQRIA IARALVRQPQ VLLLDEATSA LDPTSEKRVQ SALELASQGP TTLVVAHRLS
601: TITNADKIVF LKDGVVAEQG THEELMERRG LYCELVSITQ RKEATEADEG AVAGRPLQKS
661: QNLSDEETDD DEEDEEEDEE PELQTSGSSR DSGFRASTRR KRRSQRRKKK KDKEVVSKVS
721: FTQLMKLNSP EWRFIVVGGI ASVMHGATFP LWGLFFGDFF GILSDGDDDV VRAEVLKISM
781: IFVGIGLMAG LGNMLQTYMF TTAGVKMTTR LRKRAFGTII GQDIAYFDDE RNSVGALCSR
841: LASDCSNVQG ATGARVGTML QAVATLVVGM VVGFVFSWQQ TLLTLVTLPL VCLSVYLEGR
901: FIMKSAQKAK ASIEEASQVA VEAITNIRTV NGLCLERQVL DQYVQQIDRV DIACRRKVRF
961: RGLVFALGQA APFLAYGISM YYGGILVAEE RMNYEDIIKV AEALIFGSWM LGQALAYAPN
1021: VNDAILSAGR LMDLFKRTST QPNPPQSPYN TVEKSEGDIV YENVGFEYPT RKGTPILQGL
1081: NLTIKKSTTV ALVGPSGSGK STCVQLLLRY YDPVSGSVNL SGVPSTEFPL DTLRSKLGLV
1141: SQEPVLFDRT IAENIAYGNN FRDDVSMQEI IEAAKKSNIH NFISALPQGY DTRLGKTSQL
1201: SGGQKQRIAI ARALVRNPKI LILDEATSAL DLESEKVVQQ ALDEARSGRT CLTIAHRLTT
1261: VRNADLICVL KRGVVVEHGT HDELMALNKI YANLYLMQQV SG