3.A.1.201.26
ABC multidrug exporter, MDR1 of 1341 aas, 12 TMSs and two ATPase domains in an MCMC arrangement. Miltefosine (hexadecylphosphocholine), the first orally available drug available to treat leishmaniasis, is pumped out of the parasite by MDR1, a P-glycoprotein-like transporter. Overexpression of LtrMDR1 increases miltefosine efflux, leading to a decrease in drug accumulation in the parasites and resistance (Pérez-Victoria et al. 2006).
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| Accession Number: | Q4Q3A6 |
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| Protein Name: | p-glycoprotein |
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| Length: | 1341 |
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| Molecular Weight: | 146912.00 |
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| Species: | Leishmania major [5664] |
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| Number of TMSs: | 11 |
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| Substrate |
drug |
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1: MPEGSERGAS AKGGSVFEWE DRQGSFSPHQ PIAEGLVERG DCCEHNDYRY GPAPQSRELI
61: DMSHTYDVYV DEGKLALVNK PADQSDSTHG GSGYDSRNPL FSAEEEVKRA AVNESVSPIA
121: IFRYADTTDR ALMIIGTIFA ICSGAGMPFF SFIFGRIAMD LMSGVGSVEL SAAKMSLIMV
181: YVGIGMFVTC GGHVLCWTVT ASRQEGRIRL NFFRAVLRQD IGWHDEHSPG ELTARMTGDT
241: HVIQNGINDK LSQGIMNGAM GIIGYIAGFA FSWELTLVMV GMMPFIIVMT AIIGNIVSKM
301: TESSLKHFAK AGSLATEVME NIRTVQVFGR EDYELQRFAE AVLHAQDRGI RKEFAGNLSA
361: AVIMALVYLS YTIAFFFGSY LVEWGRRDMA DIISTFLAVL MGSLGLGFVA PSVTAFTESR
421: AAAYAIFKAI DRVPPVDIDA DGVPVTGFEQ SIEFRNVRFS YPTRPDMILF RDLNLTIRCG
481: QKIAFSGSSG CGKSSMLGLI QRFYDPAGGT VLCDGVDMRE LCLRDWRDQI GIVSQEPNLF
541: AGTMMENVRV GKPNATEEEV IEACRQANVH DTIMSLPDQY NTPVGAVGSQ LSGGQKQRIA
601: IARALVKRPP ILLLDEATSA LDRKSEMEVQ RSLDRLMEKG GMTVIVIAHR LATIRNVDCI
661: YYVKYDGAEG SKITESGTFD ELMELGGEFA AMARIQGVST GDVRSGARGQ DCGKANDFLN
721: VILDEAALAH LDEEAPRTAR QKVPIEELAK WEVNDVNVGF RRLMGMNKDK SWAVALGILG
781: SAVGGAARPT SSILMGYMLR VLGEYSVNKN VEQLRSGTNL YAPLFILFSF ATFLGWVLHG
841: FYGYAGEHLT TKIRVLLFRQ IMRQDMNFFD IPGRDAGTLA GMLSGDCEAV HQLWGPSIGL
901: KVQTVCIVAS GVVVSFIYQW KLALVALACM PLLIGCSLAE RTMMNGYTKS KEGDTSDTIV
961: TEALSSVRTV TSFNMKADRV EAFEATLRVE TPRSVKKGII AGSIYGATQF IYYSAYALCF
1021: WYGSKLIDRG EAQFTDVMIA SMSILLGAQN AGEAGAFATK LADAERSAKR VFSVIDRVPD
1081: VDIEQPGDKD LGKGCDVDFR KVQFIYSARP KQVVLASVNL RFGDGTANGL MGQTGCGKST
1141: IIQMLARFYD RRSGLICVNG KDLSSLDIAE WRRNISVVLQ EPNLFSGTVR ENIRYAREDA
1201: TDDEVEEAAR LAQIHWEIVK WPDGYNTEVG YKGSALSGGQ KQRVAIARGL LRRPKLLLLD
1261: EATSALDNVT EAKVQEGINA YQAKYGVTSV SIAHRLTTIR HCDQIILLDS GHIIEQGSHE
1321: ELMALGGEYM MRYDLYTGAS S