3.A.1.201.30
ABCB10 transporter of 655 aas and 6 TMSs. It functions in resistance to acaricides (Koh-Tan et al. 2016). Cardiomyocyte-specific deletion of AbcB10 causes cardiac dysfunction via
lysosomal-mediated ferroptosis (Do et al. 2024). AbcB10 knockout cardiomyocytes exhibit increased ROS production, iron accumulation, and lysosomal hypertrophy (Do et al. 2024).
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| Accession Number: | G9F9U0 |
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| Protein Name: | ABCB10 transporter |
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| Length: | 655 |
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| Molecular Weight: | 71175.00 |
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| Species: | Rhipicephalus microplus (Cattle tick) [6941] |
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| Number of TMSs: | 6 |
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| Substrate |
drug, acaricide |
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1: MHAFVLSAGS QLFRQVKNRK HVLLRFISSK NGGVLSNSSA IRRVCVPPVK SLASVVLCRA
61: CSNARRVDSS ELRRLLRQAR PERFRLGAAV LLLFVSSSVM IAFPFCIGKV IDVIYTSSDN
121: AELRANLNWI CKLLTGVVVI GGLANFGRVY LMNSSAQRII NSLRKQAHAS LMQQEVAFFD
181: RNRTGDLITR LSSDTALVGM SLTQNISDGL RSAVAVFGGV GMMLYTSPQL SLVGLSVVPP
241: VAIISFAFAR RLRQVAADVQ TRLAESSATA EEQLSNIRTV RAFTKEKFEM NRYSVGLTRL
301: LDKVNTETRL RAVFFGCTGA TGNMIVLAVL YYGGILMSDG RLTVGSLSSF LLYAAYVGVS
361: IGGLGGFFTE ATKALGASKK VWEIADRVPT LPNFGGLALS NLQGQVEFHN VTFAYSSRPE
421: IEVLKKLNLS VPAGSVLAIV GPSGQGKSTL ASLLLRLYDP TSGTVTLDGI DIRELDPHFL
481: RMHVGIVSQE PTLFATSIFE NILYGAKNME ESSKEDVIRA ASEANALEFI EDLPDGFNTM
541: VGERGILLSG GQKQRIAIAR AILRDPCVLI LDEATSSLDA VSERAVQEAL KKLMVGRTVL
601: TIAHRLSTIR RADKIAVLKA GTVVEHGTYE QLMGIADGLF RRLVEHQLHD ERMSG