3.A.1.201.35
P-glycoprotein, Pgp, ABCB1, of 1241 aas and 12 TMSs with a domain order MCMC. Exports geraniol and other monoterpenes. Demissie et al. 2018 reported two structures of this homodimeric P-glycoprotein: an
outward-facing conformational state with bound nucleotide and an
inward-facing apo state, at resolutions of 1.9 Å and 3.0 Å,
respectively. Features that could be clearly visualized include ATP binding with octahedral coordination of Mg2+;
an inner chamber that significantly changes in volume with the aid of
tight connections among transmembrane helices (TMSs) 1, 3, and 6; a
glutamate-arginine interaction that stabilizes the outward-facing
conformation; and extensive interactions between TMS1 and TMS3, a property
that distinguishes multidrug transporters from floppases. These
structural elements were proposed to participate in the mechanism of the
transporter (Demissie et al. 2018).
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| Accession Number: | AIX02990 |
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| Protein Name: | AIX02990.1 ATP binding cassette transporter subfamily B1 [Lavandula angustifolia subsp. angustifolia] |
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| Length: | 1242 |
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| Molecular Weight: | |
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| Species: | Lavandula angustifolia subsp. angustifolia [1211581] |
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| Number of TMSs: | 12 |
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| Substrate |
auxin |
|---|
1: MSHQSASGTA SSLSMEDDEK KQHSAEKKTV GLAKMFSFAD RTDYLLMFVG SIGACVHGAS
61: VPVFFIFFGK MINIIGLAYL FPQQASHKIA TRWLVGMHSG ERQAAKMRMA YLRSMLNQDI
121: SIFDTESSTG EVISAITTDI IVVQDAISEK VGKFLHYISR FVAGFAIGFI RVWQISLVTL
181: SIVPLIAIAG GIYAYVATGL IARVRKSYVK AGEIAEEVIG NVRTVQAFAG EEKAVKSYTT
241: SLLETYKYGR KAGLAKGLGL GTLHCVLFLS WALLVWYTSI VVHKNIANGG ESFTTMLNVV
301: IAGLSLGQAA PDITAFIRAK AAAYPIFEMI ERNTVSKTSR SSGDGKRLSK VEGHIKFKNV
361: RFSYPSRPDV LIFSKLSLDI PLGKIVALVG GSGSGKSTVI SLIERFYEPL SGQVLLDGTD
421: IRELDLKWLR QQIGLVNQEP ALFATTIRDN ILYGKKDASN EEITRAAKLS EAINFINNLP
481: ERFETQVGER GIQLSGGQKQ RIAISRAIVK NPSILLLDEA TSALDAESEK SVQEALDRVM
541: VGRTTIIVAH RLSTIRNADM IAVVQNGAIV ETGSHEDLIS RPNSAYASLV QLQEAASLTR
601: LPSHGSAMGR PLSIRYSREG SIRYSRELSR TTRSLGASFR SEKSLSRFGG DGGESIGKPV
661: KVSSGRLYSM VRPDWFYGIS GTICAFIAGA QFPLFAVGVT QALVSYYMDW DTTCREVKKI
721: AFLFTGGAAL TVIVHAITHL SFGIMGERLT LRVREKMFTA MLRNEIGWFD DVNNNSAMLA
781: SRLASDATLL KTVVVDHSTI LLQNVGLVVT SFVIAFMLNW RLTLVVIATY PLIISGHISE
841: KLFMKGYGLD LNKAYLKANM LAGEAVSNIR TVAAFCSEEK VLDLYARELI EPSKTSFRRG
901: QAAGIFYGVS QFFIFSSYAL ALWYGSTLME KGLSGFKSVM KSFMVLIVTA LAMGETLAMA
961: PDLLKGNRMV ASVFEVLDRR TEIVGDVGEE VSRVEGTIEI KDVEFSYPSR PNVLIFKDFN
1021: VRVHSGRSIA LVGQSGSGKS SVIALILRFY DPISGKVVID GKDIKKLKVK SVRKHIGLVQ
1081: QEPALFATSI YENILYGKEG ATEAEIVEAA KLANAHSFIS SLPEGYSTRV GERGVQLSGG
1141: QKQRVAIARA ILKNPSILLL DEATSALDVE SERVVQQALD RLMKNRTTVM VAHRLSTIKN
1201: ADQISVLQDG KIIEQGTHSS LVENKDGAYY KLINLQRQQE I