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Accession Number: | P13568 |
Protein Name: | PfMDR1 |
Length: | 1419 |
Molecular Weight: | 162252.00 |
Species: | Plasmodium falciparum (isolate FC27 / Papua New Guinea) [5837] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | (+)-artemisinin, drug |
Cross database links:
Pfam: | PF00664 PF00005 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0005524
F:ATP binding
GO:0008559
F:xenobiotic-transporting ATPase activity
GO:0055085
P:transmembrane transport
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References (3)[1] “Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum.” Foote S.J.et.al. 2701941 [2] “Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events.” Triglia T.et.al. 1922044 [3] “Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.” Wilson C.M.et.al. 8426608
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP AQHRKLLFIS 61: FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS IGLVQFILSM ISSYCMDVIT 121: SKILKTLKLE YLRSVFYQDG QFHDNNPGSK LRSDLDFYLE QVSSGIGTKF ITIFTYASSF 181: LGLYIWSLIK NARLTLCITC VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG 241: IRTVASYCGE KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI 301: IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT NSLYEIINRK 361: PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS FTLKEGKTYA FVGESGCGKS 421: TILKLIERLY DPTEGDIIVN DSHNLKDINL KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY 481: SLKDLEAMEN YYEENTNDTY ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL 541: IHDFVSSLPD KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL 601: VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND DNNNNNNNNN 661: NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK SSNNGNDNGS DNKSSAYKDS 721: DTGNDADNMN SLSIHENENI SNNRNCKNTA ENEKEEKVPF FKRMFRRKKK APNNLRIIYK 781: EIFSYKKDVT IIFFSILVAG GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA 841: MFISETLKNY YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL 901: KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR ARLTKSKEIE 961: KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG LEDYFCNLIE KAIDYKNKGQ 1021: KRRIIVNAAL WGFSQSAQLF INSFAYWFGS FLIKRGTILV DDFMKSLFTF IFTGSYAGKL 1081: MSLKGDSENA KLSFEKYYPL MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN 1141: VPIYKNLSFT CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN 1201: NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL FSIVSQEPML 1261: FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK YDTNVGPYGK SLSGGQKQRI 1321: AIARALLREP KILLLDEATS SLDSNSEKLI EKTIVDIKDK ADKTIITIAH RIASIKRSDK 1381: IVVFNNPDRN GTFVQSHGTH DELLSAQDGI YKKYVKLAK