3.A.1.201.44
ATP-binding cassette transporter ABCB1, P-glycoprotein, MDR1, of 1339 aas and 12 TMSs. P-glycoprotein inhibitors differently affect Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti proliferation (Larrazabal et al. 2021). These organisms are all obligatory intracellular protozoan parasites, and of them, tariquidar treatment affected proliferation only of B. besnoiti (Larrazabal et al. 2021).
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| Accession Number: | XP_029217353.1 |
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| Protein Name: | XP_029217353.1 ATP-binding cassette transporter ABC.B1 [Besnoitia besnoiti] |
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| Length: | 1340 |
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| Molecular Weight: | |
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| Species: | Besnoitia besnoiti [94643] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MGDVPPPSPS QAWKPTDKRL RSFFAPFHFV ARGEILVLVV GLIFSLGGGA MMPIFIGLFG
61: DLLTELNTGV DMDYYVKLTA VLGVLKLVIG WVSASAFEYL SDCQETKFKR HYFASLIRQE
121: QGWFDRNDAG SLASRLDANG ALIRAGVGVK SATTLEFIAT FIGSFILAFT RSWKLTLVVS
181: AALPVIGGCG ALLAWSLQNS ERHSLDAYSS AGRVAEEALR NIRTVASLGV EDQMTRDYAS
241: KLKTAERASI KGGIVTGCGV GGLMSCVFLM YALGFWYAGG LIADDLRAAL ASATPYTSSG
301: ETPQLAFGGG DVVVVLLAVM IGAFNLGEII PDLGHYLKAS EAASDLLRII RRSSELDPFD
361: ATGAKDVALS GDIVYENVSF AYPSRPEKLI FKDLNLTIPG GKTVALVGSS GCGKSTLVQL
421: LQRLYDPTSG TVKLGDCPLK EINLAALRAG LGVVSQEPKL FSASVEENIA LGSPTPVTHI
481: EVEAAAKKAN AAGFIEDFAN KYETDCGSMG AQVSGGQKQR IAIARALVRE PSILIFDEAT
541: SALDNASEHV VQAALDALVA TTGSTTIIIA HRLSTIQRAD LIIVLGHKDG QEGSSVVQQG
601: THEELMKDEQ GLYYSLVQSQ LIGMHGDEQA DTQEQLTGEE PASDTSATSF PAAATSTIHR
661: RVSSQSGISS IKSSASLLSE QLASSKETSL SCPAAPPDVE TAKRTGWRPL KKTHAANAKE
721: SASKRHLIGL AWKHWPWFLL TLVAAIASGA AFPLSAIIFS NFIAVYFNPD PDEMEREADK
781: WGLAYAILGI AFFFIEWFKF LGIESMGAKV TTDLRQRAFT QTIHQDVAFF DDAKNSVGSL
841: MSILSSDVLV VTTGSCGNPM ALATTIAAIA AGCGVAFASS WKLALVLLSC MFVLAPANMM
901: EEKILHSQGD GDKMKPADAK DCPEQVLIEA IGGIRVVSAF GLEQHFIDRY TEGLQRDASR
961: QAKSALSVGF FWGFSQGVQY AINALGMWYG GRLIAEGATA TDIMQAIFAL LFAGISIGQT
1021: VMFSTDNARA QMAAERVFSL IERPSVTDTR DQGGRRFNDH SEKGADVAFT KVNFRYRTRP
1081: TVPVYKDLFF TVAAGETVAL VGPSGCGKST AIQLIERFYD LESDAVVERD DKSGKGKPKR
1141: KRRNGGSITF DGTELKETNV SSLRQQMGLV GQEPVLFNMS IGDNIRISNP KASEADVVAA
1201: AKQAHADTFI RSFPNGYETW VGAGGSQLSG GQKQRIAIAR ALVRKPRLLL LDEATSALDA
1261: EAERQVQQTL DELVDQGHNH GTIIVAHRLS TVKNANKIVV LSNEDGRGSR VVEVGSHDEL
1321: IKIPNGAYRQ LVNMARYSS