3.A.1.201.51 Multidrug resistance protein 1, ABCB1, of 495 aas and 6 TMSs in a 2 + 2 + 2 TMS arrangement. This system confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance (Beesley et al. 2023).
|
Accession Number: | THD20368 |
Protein Name: | THD20368.1 Multidrug resistance protein 1 [Fasciola hepatica] |
Length: | 496 |
Molecular Weight: | |
Species: | Fasciola hepatica [6192] |
Number of TMSs: | 7 |
Substrate |
drug |
---|
1: MRSYRNQPSD NDPILKTKSG VSPEDPPVSF TGLFRYADGK DTTCVVFGII LFAAVGLSLP
61: LNTYFFRDEI NKFLLPTFTE NAAQTIVIQF SCLGAAVFVV AFAASALLDI SSKRQLHRIR
121: LKYFKAVLRQ DIPWFDERSS GELIGKLSDC IDTIELGIGK KIGEFFQNIT GFLAGIIIAF
181: YVGWKLTLVA CCTLPVVAAV FIAFAFVMKI FTRKEILAYA RAGSISGEVF TAVRTIVAFG
241: GEKKELDRYT QELSKAEKVG IQKSLAVGGV DGCIGLSVYS AAALIFWYGF RLIDTEGYDA
301: GSVVLVFINI LLGSIFLGNA LPSMQYFLSA KTAAQNIYGT IERVPPIDKD GEGVILNNFH
361: GNIQFQNVSF VYPTRPEVKI LENFNLTLKS GQTVALVGPS GSGKSTIVHM LQRYYDAAAG
421: NILIEGTDIC ELDLKAYRAQ IGCVQQEPIL FEGTIADNIR MGKLDATEEE IEEAAKKANA
481: HEFISNLPEV VLVIA