3.A.1.201.52
ABCB4 of 1275 aas and probably 12 TMSs in a 6 + 6 TMS arrangement. Human ABCB1 and zebrafish (Danio rerio) AbcB4 are functionally
homologous multixenobiotic/multidrug (MXR/MDR) efflux transporters that
confer the efflux of a broad range of diverse chemical compounds from
the cell. These two transporters have different temperature dependencies as expected since Homo is warm blooded while Danio is cold blooded (Luckenbach and Burkhardt-Medicke 2024).
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| Accession Number: | E7F1E3 |
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| Protein Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
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| Length: | 1275 |
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| Molecular Weight: | 140937.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
xenobiotic |
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1: MGKKSKLKVS SDKKEENGDV SGEKNGKEEK EEKEKLEMVG PIELFRYADS IDILLMMLGL
61: IMSMANGAVL PLMVIVFGDM TDSFVDDTLL DNLKNITLPP NFTFPETSNI TLGEKMTTHA
121: IYYSIMGFVV LVAAYMQVAF WTLAAGRQVK KLRKIFFHSI MKQEIGWFDV NETGQLNTRL
181: TDDVYKINEG IGDKLGMLIQ NLTTFIVGII IGFAKGWKLT LVILAVSPLL GISAAVIGKV
241: MTTFTSKEQT AYAKAGAVAE EVLSSIRTVF AFGGQKKEIK RYHKNLEDAK NVGVRKAITV
301: NIAMGFTFFM IYMSYALAFW YGSTLILGGE YTIGMLLTIF FAVLIGAFGL GQTSPNIQTF
361: SSARGAAHKV FQIIDHEPKI NSFSEEGYKL DVVKGNIEFK NIHFRYPSRD DVKVLNGMNL
421: KVMSGQTIAL VGSSGCGKST TIQLLQRFYD PQEGSVSIDG HDIRSLNVRG LRELIGVVSQ
481: EPVLFATTIA ENIRYGRQDV TQDEIEQAAR EANAYNFIMK LPDKFETLVG DRGTQMSGGQ
541: KQRIAIARAL VRNPKILLLD EATSALDAES ETIVQAALDK VRLGRTTIVV AHRLSTIRNA
601: DVIAGFQNGE IVELGTHDEL MERKGIYHSL VNMQMFKSTE VAEEDSEEMT MDEKSPSVSS
661: MNERTLFRQK SRSGSEKELK EEEKPTEEEK VPNVSFLTVL KLNYPEWPYM VVGILCATIN
721: GGMQPAFAVI FSKIIAVFAE PDQNLVRQRC DLYSLLFAGI GVLSFFTLFL QGFCFGKAGE
781: LLTMRLRFKA FNAMMRQDLA WYDDTKNSVG ALTTRLAADT AQVQGATGVR LATLAQNVAN
841: LGTAIVISFV YGWQLTLLIL SIVPIMAVAG AIQMKLLAGH ALKDKKELEQ AGKIATEAIE
901: NVRTVVSLTR ESKFESLYEE NLIVPYKNAK KKAHVFGLTF SFSQAMIYFA YAGCFKFGSW
961: LIEQKLMTFE GVFLVISAVV YGAMAVGEAN SFTPNYAKAK MSASHVLMLI NRAPAIDNSS
1021: EDGDKPDKFE GNVGFEHVYF KYPSRPDVPV LQGLKLRVKK GQTLALVGSS GCGKSTTIQL
1081: LERFYDPQQG RVMLDDNDAK QLNIHWLRSQ IGIVSQEPVL FDCSLAENIA YGDNSREVDQ
1141: EEIVEAAKAA NIHSFIENLP QRYQTQAGDK GTQLSGGQKQ RIAIARAILR NPKVLLLDEA
1201: TSALDTESEK IVQDALDKAS KGRTCIIVAH RLSTIQNADC IAVVQNGVVV EQGTHQQLLS
1261: QQGAYYTLVT SQMSH