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| Accession Number: | Q90Z35 |
| Protein Name: | BSEP |
| Length: | 1348 |
| Molecular Weight: | 148649.00 |
| Species: | Raja erinacea (Little skate) [7782] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | taurocholic acid, bile acid |
Cross database links:
| Pfam: | PF00664 PF00005 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0005524
F:ATP binding
GO:0042626
F:ATPase activity, coupled to transmembrane m...
GO:0055085
P:transmembrane transport
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References (1)[1] “Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.” Cai S.Y.et.al. 11447010
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MPNSVVLRRF NSLGEDNKAF QAEYLDIDGP GQRKVYTVNG NYPSKSKDDN ENLSKKGDRI 61: KIGFFQLFRF ASCYEVTLMV FGGVCALLHG VAQPAVLLVF GLLTDTFIAY DIELQELKDT 121: RKHCDNNTIH WVNGSEYLNQ HNETMSCGIL NIEKEMTMFA YYYVGIGCSV LLLGYFQICF 181: WVTAAARQTQ KIRKAYFRQI MRMEMGWFDC NSVGELNTRM SDDINKINDA IADQVGIFIQ 241: RFSTFVSGFL MGFVNGWKLT LVIIAVSPLI GLGAALMALS VARLTGLGLK AYAKAGAVAD 301: EVLSSIRTVA AFSGEKKEVD RYDRNLVFAQ RWGIRKGMIM GFFTGYVWMI IFCCYALAFW 361: YGSKLVIEQN EYTPGGLLQV FLGVLVAAMN LGQASPCLEA FASGRGAAVK IFETIDREPE 421: IDCMSEGGYT LNKVKGDIEF HNVTFNYPSR PDVKTLDRLS MVIKAGETTA FVGPSGSGKS 481: TAVELIQRFY DPKQGMVTLD GHDIRSLNIQ WLRSLIGIVE QEPVLFSTTI EENIRYVREG 541: LTKNDIVQAA KEANAYDFIM DLPEKFNTLV GEGGGQMSGG QKQRIAIARA LVRNPKILLL 601: DMATSALDNE SEAIVQGALD KVRFGRTTIS IAHRLSTVRN VDVIIGFEHG RAVERGRHAE 661: LLERKGIYFT LVTLQTQGEQ ALHEKARQVN GAIEDGASEK RQLIRRGSSR ASVRSTRHQR 721: SRSQVSEVLS DLSGPGDVAS AVRTPSISLG DEDKDVEEEE ESIEPAPVSR ILKYNVSEWP 781: YMLFGSLGAA VNGGVNPIYA LLFSQILGTF SLQNEEEKIN QINAICLFFV VVGLVSFLTQ 841: FLQSYFFAKS GELLTRRLRK LGFQAMLRQE IGWFDDRKNS PGTLTTRLAT DASQVQGATG 901: TQIGMIVNSI TNIGVSLIIA FYFSWKLTLV ILCFLPFLAL TGALQARMLT GFANQDKEAL 961: EAAGQISSEA LSNIRTIAGL AKEKMFVQLF EAQLEAPYKA AIKKANVYGL CFGFAQSVIF 1021: LANAASYRFG GYLVVAENLH FSIVFRVISA IVTSGTALGR ASSYTPDYAK AKIAAARFFQ 1081: LIDRAPKINI DSSEGEKWSN FRGDIKFVEC TFTYPTRPDF QVLNGLSVCV MPGQTLAFVG 1141: SSGCGKSTSV QLLERFYDPN QGRVIIDGRS TTNVNTAFLR SKIGIVSQEP VLFDSSIEEN 1201: IKYGDNSRQV SMDEVIAAAK KAQLHSFVMS LPEKYGTRVG AQGSQLSRGQ KQRIAIARAI 1261: VRDPKILLLD EATSALDTES EKIVQDALDE ARKGRTCIVI AHRLSTIQNS DIIAVMSRGI 1321: IIEQGSHGNL MAAKGAYYKL VTTGAPIS