3.A.1.204.15
MDR efflux pump, ABCG2a. Exports canonical MDR susbtrates such as
calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).
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| Accession Number: | I0DHI9 |
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| Protein Name: | ATP-binding cassette transporter subfamily G member 2a |
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| Length: | 703 |
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| Molecular Weight: | 77971.00 |
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| Species: | Strongylocentrotus purpuratus (Purple sea urchin) [7668] |
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| Number of TMSs: | 6 |
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| Substrate |
mitoxantrone |
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1: MEGEEHEQDT HFGATEETPT TVAPSRDPEN DQPAVLEVNH NDTGPGDMKI NMDPVLSDPE
61: KHKLGYGSVT NGHSSHTKVH PSFARSTSID GSVVSFHAIT YTVKTKENRK KVTKTILTDV
121: NGLFKPGMNA ILGPTGSGKT SLLDVLAARK DPDGLSGQVL IDGAPQPKNF KCVSGYVVQD
181: DVVMGTLTIR ENLQFSAALR LPKTVGKKER EDRVDDILAE LGLSHVGDSK VGTEFIRGVS
241: GGERKRTNVG MELITKPSVL FLDEPTTGLD ASTANAVMHL LASLSKRGRT IIFSIHQPRY
301: SIFRLFDKMH LLGQGRTIYH GPAQEALEYF SSIGFECEEH NNPPDFFLDV ILGQSDLKSS
361: EKDQEDVESG VAAIENGEKS KVILADCYEK SHYNKTMKEA TESIYTQYRN DEEPSIVSIN
421: YPTSFFSQLY HVSHRAVLNI LRNPFLTVIQ NATVILFSVV IGGIYFQLDT SISSGYQNRI
481: GAFFFLIMQM VFGNLSAVEL FIRERVIFIH ESASGFYRVS VYFVAKVFCD LLPLRVIPTI
541: LYVVVTYWMI GLQADATKFF LYFLTLLLVT FVSSALAFAI SSSVSIAGIA TLLIAMCYVL
601: MMVFGGLLVN ISSLPVWLQW LQYLSIFRFG LNALLINEMV GLDFCETVGN VTLRCIPGTD
661: YLDQQGIDYS DWGLWQNEMA LGIMTVALLA IAYIQLRRIP KLK