3.A.1.204.17
Scarlet. Part of a membrane-spanning permease system necessary for the transport
of pigment precursors into pigment cells responsible for eye color. The scarlet and white (TC# 3.A.1.204.1) complex probably transports a metabolic intermediate (such as
3-hydroxy kynurenine) from the cytoplasm into the pigment granules (Tearle et al. 1989). These proteins are located in the
membranes of pigment granules within pigment cells and retinula cells
of the compound eye (Mackenzie et al. 2000). Knockouts of scarlet in the noctuid moth, Helicoverpa armigera, are viable and produce pigmentless first instar larvae and yellow adult
eyes lacking xanthommatin (Khan et al. 2017).
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| Accession Number: | P45843 |
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| Protein Name: | Protein scarlet |
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| Length: | 666 |
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| Molecular Weight: | 74458.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
3-hydroxykynurenine |
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1: MSDSDSKRID VEAPERVEQH ELQVMPVGST IEVPSLDSTP KLSKRNSSER SLPLRSYSKW
61: SPTEQGATLV WRDLCVYTNV GGSGQRMKRI INNSTGAIQP GTLMALMGSS GSGKTTLMST
121: LAFRQPAGTV VQGDILINGR RIGPFMHRIS GYVYQDDLFL GSLTVLEHLN FMAHLRLDRR
181: VSKEERRLII KELLERTGLL SAAQTRIGSG DDKKVLSGGE RKRLAFAVEL LNNPVILFCD
241: EPTTGLDSYS AQQLVATLYE LAQKGTTILC TIHQPSSQLF DNFNNVMLLA DGRVAFTGSP
301: QHALSFFANH GYYCPEAYNP ADFLIGVLAT DPGYEQASQR SAQHLCDQFA VSSAAKQRDM
361: LVNLEIHMAQ SGNFPFDTEV ESFRGVAWYK RFHVVWLRAS LTLLRDPTIQ WLRFIQKIAM
421: AFIIGACFAG TTEPSQLGVQ AVQGALFIMI SENTYHPMYS VLNLFPQGFP LFMRETRSGL
481: YSTGQYYAAN ILALLPGMII EPLIFVIICY WLTGLRSTFY AFGVTAMCVV LVMNVATACG
541: CFFSTAFNSV PLAMAYLVPL DYIFMITSGI FIQVNSLPVA FWWTQFLSWM LYANEAMTAA
601: QWSGVQNITC FQESADLPCF HTGQDVLDKY SFNESNVYRN LLAMVGLYFG FHLLGYYCLW
661: RRARKL