3.A.1.204.39
ABCG2/BCRP1 porter of 656 aas and 6 C-terminal TMSs in a 2 + 3 + 1 TMS arrangement. Expression and regulation by sex steroids in the Harderian gland of the Syrian hamster has been demonstrated (Mares et al. 2019). It may be involved in protoporphyrin IX transport and of other intermediates in heme biosynthesis. This protein is 82% identical to the human otholog (TC# 3.A.1.204.2).
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| Accession Number: | AMA11217.1 |
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| Protein Name: | AMA11217.1 ATP-binding cassette protein G2 [Mesocricetus auratus] |
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| Length: | 657 |
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| Molecular Weight: | |
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| Species: | Mesocricetus auratus [10036] |
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| Number of TMSs: | 6 |
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| Substrate |
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1: MSSSNDHVLV PMPQRNTNGL PGMNASDMKT LTGDVLSFHH ITYRVKVKSG FFVRKTVEKE
61: ILSDINGIMK PGLNAILGPT GGGKSSLLDV LAARKDPRGL SGDVLINGAP QPANFKCTSG
121: YVVQDDVVMG TLTVRENLQF SAALRLPETM KSHEKNERIN KVIKELGLDK VADSKVGTQF
181: TRGVSGGERK RTSIGMELIT DPSILFLDEP TTGLDSSTAN AVLLLLKRMS KQGRAIIFSI
241: HQSRYSIFKL FDSLTLLASG KLMFHGPAQE ALEYFASAGY HCEPYNNPAD FFLDVVNGDS
301: SAVVLNREEG EQEANKTEEP SKREKPIIET LAEFYANSPV YRETKADLDR LPVAQKKKGM
361: SAFKESTYVT SFCHQLRWIA KRSFKNLLGN PQASIAQIIV TIILSLVIGA IYFDLKNDRS
421: GIQNRAGVLF FLTTNQCFTS VSAVELFVVE KKLFIHEYIS GYYRVSSYFF GKLMSDLLPM
481: RLLPSVIFTC ILYFMLGLKK EPGAFFIMMF SLMMVAYTAS SMALAIAAGQ SVVSVATLLM
541: TISFVFMMIF SGLLVNLKTI EPWPSWLQYF SIPRYGYTAL QYNEFLGQDF CPGLNATANE
601: TCSNSFAICT GDEYLESQGI ELSPWGLWQN HVALACMIII FLTIAYVKLL FLKKYS