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3.A.1.205.24
Multidrug resistance (MDR) exporter, (Np)AbcG5/PDR5 of 1498 aas and 12 TMSs.  NpABCG5/NpPDR5 is barely expressed in leaf tissues under normal conditions, but its expression is induced by the biotic stress hormone methyl jasmonate, or when tissues are wounded or chewed by an insect. NpABCG5/NpPDR5 confers resistance to the herbivore Manduca sexta (Toussaint et al. 2017).  The same system, ABCG5 of soybean plays a role in iron homeoistasis and the iron deficiency response (Wang et al. 2023). ElABCG39 is a key player in ingenol transmembrane efflux identified through genome-wide analysis of ABC transporters in Euphorbia lathyris L (Lin et al. 2024).

Accession Number:I6XGC6
Protein Name:Pleiotropic drug resistance transporter 5
Length:1498
Molecular Weight:169614.00
Species:Nicotiana plumbaginifolia (Leadwort-leaved tobacco) [4092]
Number of TMSs:15
Substrate iron cation, drug

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEANGGPRRL GSSRSSMSRT MSRSRSRASW NVEDVFNPMP SRRSTRGEED EEALTWAALE 
61:	KLPTYDRLRK TVLKSVMESE NNQGNKKVVH KEVDVRNLGM NERQEFIDRV FRVAEEDNEK 
121:	FMRKFRNRID KVGITLPTVE VRYEHLTIEA DCYIGDRALP TLPNAARNIA ESALSCVGIT 
181:	LAEKTKLTIL KDASGIIKPS RMTLLLGPPS SGKTTLLLAL AGKLDPTLKV RGEITYNGHG 
241:	LKEFVPQKTS AYISQNDVHV AEMTVKETLD FSARCQGVGS RYELLTELAR RERDAGIFPE 
301:	AEIDLFMKAT AMEGVESSLI TDYTLRILGL DVCRDTIVGD EMIRGISGGQ KKRVTTGEMI 
361:	VGPTKTLFTD EISTGLDSST TFQIVKCLQQ IVHLTEATVL MSLLQPAPET FDLFDDIILL 
421:	SEGQIVYQGP REHVLEFFET CGFRCPERKG TADFLQEVTS RKDQEQYWAN RHRPYQYISV 
481:	TEFAKRFKRF HVGLRIENEL SVPYDKTRSH PAALIFKKYT VPILELLKTN FDKEWLLIKR 
541:	NSFVYVFKTV QIIIVALIGS TVFLRTKMHT NTVDDGAIYV GALLFGMVIN MFNGFSELAM 
601:	IIQRLPVFYK HRDLLFHPPW TFTLPTVLLK VPISVFETIV WMVMTYYTIG YAPEASRFFK 
661:	QSLLTFLIQQ MAAGLFRLTA GVCRTMIIAN TGGALMLLLI FLLCGFILPR GSIPDWWRWG 
721:	YWVSPLSYGF NAFTVNEMFA PRWMNKFGPD GTTRLGLQVM KNFDVFTERR WFWIGAAALL 
781:	GFTILFNVLF TLVLVYLSPL NKPQATLSKE QASDMEADQE ESTGSPRLRI SQSKRDDLPR 
841:	SLSAADGNKT REMEIRRMSS RTSSSGFYRN EDANLEAANG VAAKKGMILP FTPLAMSFDD 
901:	VSYFVDMPPE MKDQGVTEDK LQLLREVTGA FRPGVLTALM GVSGAGKTTL MDVLAGRKTG 
961:	GYIEGDVRIS GFPKNQETFA RVSGYCEQTD IHSPQVTIHE SLIFSAFLRL PKEVSKEDKM 
1021:	IFVDEVMDLV ELDNLKDAIV GLPGVTGLST EQRKRLTIAV ELVANPSIIF MDEPTSGLDA 
1081:	RAAAIVMRTV RNTVDTGRTV VCTIHQPSID IFEAFDELLL MKRGGQVIYA GPLGRHSQKI 
1141:	IEYFEAIPGV QKIKEKYNPA TWMLEASSIG TEARLGMDFA EYYRSSALHQ RNKALVKELS 
1201:	APPPGAKDLY FTTQFSQPAW GQFKSCLWKQ WWTYWRSPDY NLVRFFFSLA AALLIGTIFW 
1261:	NVGSKRKSSG DLMTVIGAMY AAVLFVGINN CSTVQPIVAV ERTVFYRERA AGMYSALPYA 
1321:	MAQVFAEIPY ILVQTTYYTL IIYAMVGFEW TAAKFFWFYF VTFFSFLYWT YYGMMTVSIT 
1381:	PNHQVAAIFA AAFYALFNLF SGFFIPRPRI PKWWIWYYWI CPVAWTVYGS IVSQYGDVED 
1441:	TIQVPGVFPN PRIKDYIKDH FGYSSDFMAP VAVVLVGFAA FFAFMYAYAI KTLNFQTR