3.A.1.205.27
Multidrug resistance efflux pump of 1567 aas and 12 TMSs. Probably exports many drugs including griseofulvin, itraconazole, terbinafine and amphotericin B (Martins et al. 2016).
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| Accession Number: | F2SHL1 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 1567 |
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| Molecular Weight: | 174752.00 |
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| Species: | Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus) [559305] |
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| Number of TMSs: | 11 |
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| Substrate |
drug, drug |
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1: MASQPPQPLS GQPVTQYEEY QSEVITETTN RPTPAADIYE ITPTNDVMDD RYEHEHDDYE
61: SGAMYETVRT WSPQSRPELV RIASVFSRVD SHPNVTPTTE DGGQLNRRDT LAGVKIGDPV
121: LDPTKPEFDF YKWARMFTHV MENEGIKRNR TGVMFRNLTV LGSGSAVQYQ DTFLSPFAAP
181: FRPGELCGKG RNPEKVILHD FNGAIREGEL LMVLGRPGSG CSTFLKAICG ELHGLQKKKE
241: SIIHYNGVSQ HTFKKELRGE AVYSAEDEHH FPHLTVGQTL EFAAAARTPS KRVLGVSRKD
301: FSTHLARVMM SVFGLSHTYN TKVGDDYVRG VSGGERKRVS IAEIALSGAP ICCWDNSTRG
361: LDSATALEFT KALKIGSQVG GITQCLAIYQ ASQAIYDIFD KVIVLYEGRQ IFFGPTRIAK
421: QYFEEMGWYC PPRQTTADFL TSVTNPKERI AKEGYENRVP RTAVDFERYW KQSQNNKLLL
481: ANMDRFEAEY PPEEGHLQKL RETHGQAQAK HTTSKSPYRI SVPMQVKLCT VRAYQRLWGD
541: KSSTIATNIS QIMMALIIGS LFFDTPQTTD GFFAKGSVIF FAILLNGLMS ITEINGLCKT
601: TDPIVPNAQR PIVVKHVNFA FYHAYSEALA GIVADIPIKF LLALVFNIII YFLGGLERSA
661: AKFFIFFLFT FITILTMSAI FRTLAAATKT IPQALALAGV MILALVIYTG FALQPSYMHP
721: WFKWILYINP IAYAYEALLV NEVHGNRYRC ATPVPPYGGG KNFACAVAGA VPGEMSVSGD
781: AWVESSYDYS YAHIWRNLGI LLGFLAFFYF VYLMVSELNL SSASSAEFLV FRRGHLPKSF
841: QGSKDEEAAA GGVMHPNDPA RLPPTNTNGA AGETAPGGST VAVIPPQKDI FTWRNVTYDI
901: TIKGEPRRLL DNISGWVRPG TLTALMGVSG AGKTTLLDAL AQRTTMGVIT GDMLVNGRPL
961: DSSFQRKTGY VQQQDLHLET TTVREALRFS ADLRQPKSVS RKEKYEYVED VIKMLSMEDF
1021: SEAVVGNPGE GLNVEQRKLL TIGVELAAKP QLLLFLDEPT SGLDSQSSWS IVTFLRKLAD
1081: NGQAVLSTIH QPSGILFEQF DRLLFLAKGG RTVYFGDIGK NSETLLNYFE THGAEPCGPS
1141: ENPAEYMLNI VGAGPSGKSK IDWPVVWKES EESRHVQQEL DQIQSETSKK NEGHGQSAEK
1201: EPGEFAMPFT SQLYCVTTRV FQQYWRTPSY IWGKFLLGLA SALFIGFSFF LQNSSMAGLQ
1261: NSLFSIFMLT TIFSSLVQQI MPRFVTQRDL FEVRERPSRA YSWKVFLLAN IIVEIPYQIL
1321: LGIIAWASLF YPTFGAHLSS ERQGILLLYC VQFFIFASTF AQMIIAGLPD AETAGGIATT
1381: MFGLMVTFNG VLQKPNALPG FWRFMWRVSP ITYTVGGLAA TSLHNREVKC AQNELAIFDP
1441: PTGATCAQYL QKLVEAGAPG KLYNPTSTTQ CQYCPLSSGD QFLGGSEIHW SDRWRNFGIG
1501: WAYIVFNIFA TVALYYLIRV RKSSGRPNRI ISVIMYHLSR AGTYCRAFIT GRKEKCPRKR
1561: EQIGKIY