3.A.1.205.32 MDR exporter, TmrMDR3, of 1503 aas and 12 TMSs in a C-M-C-M domain arrangement. Four ABC transporters (TruMDR1, TruMDR2, TruMDR3, and TruMDR5) and a second MFS transporter (TruMFS2) proved to be able to operate as azole efflux pumps. Milbemycin oxime inhibited only TruMDR3. TruMDR3 transports voriconazole (VRC) and itraconazole (ITC), while TruMDR2 transports only ITC. Disruption of TruMDR3 abolished resistance to VRC and reduced its resistance to ITC (Monod et al. 2019).
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Accession Number: | F2SG60 |
Protein Name: | ABC multidrug transporter MDR3 |
Length: | 1503 |
Molecular Weight: | 169082.00 |
Species: | Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus) [559305] |
Number of TMSs: | 13 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
azole, itraconazole |
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1: MAPTEEANVT KPTGELRPDE KLNYEEDVKC SGSSSTTVGK TAYDTDDISQ SQAAELQDLA
61: RQLSRASRQG GLDVENEPQQ VINPFLDSES DPELNPDSKS FNVAKWLKTI LQITSRDPER
121: FPKRTAGVSF RNMNVHGYGT AADYQSDVGN LPLKAWSGIM SMLGLRKKVR IDILRDFEGL
181: VKSGEMLVVL GRPGSGCSTL LRTLSGETHG LYLDEGNDIQ YQGISWEQMH KNFRGEVIYQ
241: AETETHFPQM TVGDTLYFAA RARAPANRLP GVSREQYAIH MRSMVMSMLS LSHTINTQVG
301: NEYIRGVSGG ERKRISIAET TLSGSPLQCW DNSTRGLDSA NALEFVKSLR LSTKYSGTTA
361: IVAIYQAGQA IYDIFDKAVV LYEGHQIYFG NAVRAKEYFI EMGFDCPSRQ TTADFLTSVT
421: SPSERRVRPG YESRVPQTPA EFAQRWKESE DRRILMQEID EYNKTYPLHG EQLQKFQASR
481: LAEKSRSTSK SSPYTLSYPM EIKLCMWRGF QRLKGDMSMT LTSIIGNIAM SLIIASVFYN
541: QQETTDSFFS RGSLLFFAIL MNAFASSLEI LTLWHQRPIV EKHDKYALYH PSSEAISSIL
601: VDMPAKLAVA IVFNLIIYFM TNLRRTPGHF FIFFLFSFTT TLTMSNVFRS IAAVSRTLSQ
661: ALVPTSIFML ALVIYTGFTI PVRDMRPWFK WISYINPIQY AFESLMINEF HDREFKCAVY
721: IPSGPGYSNV SGTSKICAAK GAMAGKPTVS GDVFLRETYS YYASHMWRNY GIIVAFFLFF
781: LFVYITATEL VSAKPSKGEI LVFPKGKVPA FLKQSKKKQD PEAASTQEKQ PVETSGHDQT
841: AAIVKQTSVF HWESVCYDIK IKKESRRILD NVDGWVKPGT LTALMGVSGA GKTTLLDVLA
901: NRVTMGVVTG EMLVDGRLRD DSFQRKTGYV QQQDLHLEIS TVREALTFSA LLRQPNTTPY
961: EEKVAYVEEV IKMLGMEEYA NAVVGVLGEG LNVEQRKRLT IGVEIAAKPD LLLFFDEPTS
1021: GLDSQTAWSI CTLMRKLADH GQAVLCTIHQ PSAMLMQEFD RLLFLASGGR TVYFGELGKH
1081: MSTLIEYFES KGAPKCPPDA NPAEWMLEVI GAAPGSKTDI DWPAVWRDSA ERVEVRRHLA
1141: ELKSELSQKP QTPRLTGYGE FAMPLWKQYL IVQHRMFQQY WRSPDYIYSK ACLAIVPTLF
1201: IGFTFYKEQV SLQGIQNQMF AIFMFMILFP NLVQQMMPYF VIQRSLYEVR ERPSKTYSWI
1261: AFMISSVVVE IPWNALLTVP AFFCWYYPIG FYKNAIPTDA VTERSGTMFL LILIFLMFSS
1321: TFSSMVIAGI EQAETGGNIA QLCFSLTLVF CGVLVSPTAM PGFWIFMYRL SPFTYFVSAV
1381: LSTGVGRTDI VCAANEILRL TPAAGQTCME YLGPYTKFAG GRILTPDATD MCEFCAVADT
1441: DTFLKGVNII FDERWRNIGI LFGYIAFNMV GAIGLYWLLR VPKRKSGVKQ GQQPQKQANE
1501: TKA