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| Accession Number: | P21441 |
| Protein Name: | PgpA |
| Length: | 1548 |
| Molecular Weight: | 172236.00 |
| Species: | Leishmania tarentolae (Sauroleishmania tarentolae) [5689] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | arsenite(3-), antimonite, glutathione conjugate |
Cross database links:
| Pfam: | PF00664 PF00005 PF01302 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0005524
F:ATP binding
GO:0008559
F:xenobiotic-transporting ATPase activity
GO:0046677
P:response to antibiotic
GO:0055085
P:transmembrane transport
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References (1)[1] “The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene.” Ouellette M.et.al. 1969794
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVDNGHVTIA MADLGTVVEI AQVRCQQEAQ RKFAEQLDEL WGGEPAYTPT VEDQASWFQQ 61: LYYGWIGDYI YKAAAGNITE ADLPPPTRST RTYHIGRKLS RQAHADIDAS RRWQGYIGCE 121: VVYKSEAEAK GVLRWVGHLQ QSDYPRSLVA GVEWRMPPRH RRLAVLGSAA ALHNGVVHGE 181: RLFWPHEDNY LCSCEPVEQL YVKSKYNLIP PRPPPSPDLL RTLFKVHWYH VWAQILPKLL 241: SDVTALMLPV LLEYFVKYLN ADNATWGWGL GLALTIFLTN VIQSCSAHKY DHISIRTAAL 301: FETSSMALLF EKCFTVSRRS LQRPDMSVGR IMNMVGNDVD NIGSLNWYVM YFWSAPLQLV 361: LCLLLLIRLV GWLRVPGMAV LFVTLPLQAV ISKHVQDVSE RMASVVDLRI KRTNELLSGV 421: RIVKFMGWEP VFLARIQDAR SRELRCLRDV HVANVFFMFV NDATPTLVIA VVFILYHVSG 481: KVLKPEVVFP TIALLNTMRV SFFMIPIIIS SILQCFVSAK RVTAFIECPD THSQVQDIAS 541: IDVPDAAAIF KGASIHTYLP VKLPRCKSRL TAMQRSTLWF RRRGVPETEW YEVDSPDASA 601: SSLAVHSTTV HMGSTQTVIT DSDGAAGEDE KGEVEEGDRE YYQLVSKELL RNVSLTIPKG 661: KLTMVIGSTG SGKSTLLGAL MGEYSVESGE LWAERSIAYV PQQAWIMNAT LRGNILFFDE 721: ERAEDLQDVI RCCQLEADLA QFCGGLDTEI GEMGVNLSGG QKARVSLARA VYANRDVYLL 781: DDPLSALDAH VGQRIVQDVI LGRLRGKTRV LATHQIHLLP LADYIVVLQH GSIVFAGDFA 841: AFSATALEET LRGELKGSKD VESCSSDVDT ESATAETAPY VAKAKGLNAE QETSLAGGED 901: PLRSDVEAGR LMTTEEKATG KVPWSTYVAY LKSCGGLEAW GCLLATFALT ECVTAASSVW 961: LSIWSTGSLM WSADTYLYVY LFIVFLEIFG SPLRFFLCYY LIRIGSRNMH RDLLESIGVA 1021: RMSFFDTTPV GRVLNRFTKD MSILDNTLND GYLYLLEYFF SMCSTVIIMV VVQPFVLVAI 1081: VPCVYSYYKL MQVYNASNRE TRRIKSIAHS PVFTLLEESL QGQRTIATYG KLHLVLQEAL 1141: GRLDVVYSAL YMQNVSNRWL GVRLEFLSCV VTFMVAFIGV IGKMEGASSQ NIGLISLSLT 1201: MSMTLTETLN WLVRQVAMVE ANMNSVERVL HYTQEVEHEH VPEMGELVAQ LVRSESGRGA 1261: NVTETVVIES AGAASSALHP VQAGSLVLEG VQMRYREGLP LVLRGVSFQI APREKVGIVG 1321: RTGSGKSTLL LTFMRMVEVC GGVIHVNGRE MSAYGLRDVR RHFSMIPQDP VLFDGTVRQN 1381: VDPFLEASSA EVWAALELVG LRERVASESE GIDSRVLEGG SNYSVGQRQL MCMARALLKR 1441: GSGFILMDEA TANIDPALDR QIQATVMSAF SAYTVITIAH RLHTVAQYDK IIVMDHGVVA 1501: EMGSPRELVM NHQSMFHSMV ESLGSRGSKD FYELLMGRRI VQPAVLSD