3.A.1.31.3 RLI1 ATPase of 608 aas and 0 TMSs, ABCE. Binds to the ribosome, IF3, IF5 and IF2 to promote preinitiation complex assembly (Dong et al. 2004). ABCE proteins
are present in eukaryotes and archaea and are encoded by a single
gene in most genomes, or by two genes in a few cases. Functional
analysis of ABCE genes, primarily in Saccharomyces cerevisiae, has shown that ABCE proteins have essential functions as part of the translational
apparatus. Navarro-Quiles et al. 2018 summarized ABCE protein functions in ribosome biogenesis and recycling, with a
particular focus on their known and proposed developmental roles in
different species. The ABCE proteins might represent another class of factors contributing to the role of the ribosome in gene expression regulation.
|
Accession Number: | KZV12328 |
Protein Name: | KZV12328.1 RLI1 [Saccharomyces cerevisiae] |
Length: | 609 |
Molecular Weight: | |
Species: | Saccharomyces cerevisiae [4932] |
Substrate |
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1: MSDKNSRIAI VSADKCKPKK CRQECKRSCP VVKTGKLCIE VTPTSKIAFI SEILCIGCGI
61: CVKKCPFDAI QIINLPTNLE AHVTHRYSAN SFKLHRLPTP RPGQVLGLVG TNGIGKSTAL
121: KILAGKQKPN LGRFDDPPEW QEIIKYFRGS ELQNYFTKML EDDIKAIIKP QYVDNIPRAI
181: KGPVQKVGEL LKLRMEKSPE DVKRYIKILQ LENVLKRDIE KLSGGELQRF AIGMSCVQEA
241: DVYMFDEPSS YLDVKQRLNA AQIIRSLLAP TKYVICVEHD LSVLDYLSDF VCIIYGVPSV
301: YGVVTLPASV REGINIFLDG HIPAENLRFR TEALQFRIAD ATEDLQNDSA SRAFSYPSLK
361: KTQGDFVLNV EEGEFSDSEI LVMMGENGTG KTTLIKLLAG ALKPDEGQDI PKLNVSMKPQ
421: KIAPKFPGTV RQLFFKKIRG QFLNPQFQTD VVKPLRIDDI IDQEVQHLSG GELQRVAIVL
481: ALGIPADIYL IDEPSAYLDS EQRIICSKVI RRFILHNKKT AFIVEHDFIM ATYLADKVIV
541: FEGIPSKNAH ARAPESLLTG CNRFLKNLNV TFRRDPNSFR PRINKLDSQM DKEQKSSGNY
601: FFLDNTGI