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4.A.4 The PTS Glucitol (Gut) Family

The Gut family consists only of glucitol-specific porters, but these occur both in Gram-negative and Gram-positive bacteria. IIGut of E. coli consists of three proteins, a IIA protein, a putative 4 TMS IIC2 protein and a putative 4 TMS IIC1 protein (Nguyen et al., 2006). The N- and C-termini as well as the IIB domain may thereby be localized to the cell cytoplasm, but the topology has not been established experimentally. IIAGut is believed to be phosphorylated on a histidyl residue, while IIBGut is probably phosphorylated on a cysteyl residue. However, these possibilities have not been demonstrated experimentally.

This family belongs to the: PTS-GFL Superfamily.

References associated with 4.A.4 family:

Nguyen, T.X., M.R. Yen, R.D. Barabote, and M.H. Saier, Jr. (2006). Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J. Mol. Microbiol. Biotechnol. 11: 345-360. 17114898
Reizer, J., W.J. Mitchell, N. Minton, J. Brehm, A. Reizer, and M.H. Saier, Jr. (1996). Proposed topology of the glucitol permeases of Escherichia coli and Clostridium acetobutylicum. Curr. Microbiol. 33: 331-333. 8875915
Tangney, M., J.K. Brehm, N.P. Minton, and W.J. Mitchell. (1998). A gene system for glucitol transport and metabolism in Clostridium beijerinckii NCIMB 8052. Appl. Environ. Microbiol. 64: 1612-1619. 9572925
Testa, C.A., R.M. Cornish, and C.D. Poulter. (2004). The sorbitol phosphotransferase system is responsible for transport of 2-Cmethyl-D-erythritol into Salmonella enterica serovar typhimurium. J. Bacteriol. 186: 473-480. 14702317
Yamada, M. and M.H. Saier, Jr. (1987). Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli: Nucleotide sequence of the gut operon. J. Biol. Chem. 262: 5455-5463. 3553176