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|---|---|
| Accession Number: | Q9NPH5 |
| Protein Name: | KOX-1 |
| Length: | 578 |
| Molecular Weight: | 66932.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 5 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | Electrons |
Cross database links:
| RefSeq: | NP_001137308.1 NP_058627.1 |
|---|---|
| Entrez Gene ID: | 50507 |
| Pfam: | PF08022 PF01794 PF08030 |
| OMIM: |
605261 gene |
| KEGG: | hsa:50507 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0005925
C:focal adhesion
GO:0016021
C:integral to membrane
GO:0005634
C:nucleus
GO:0009055
F:electron carrier activity
GO:0050660
F:FAD binding
GO:0020037
F:heme binding
GO:0016174
F:NAD(P)H oxidase activity
GO:0019826
F:oxygen sensor activity
GO:0007569
P:cell aging
GO:0000902
P:cell morphogenesis
GO:0006954
P:inflammatory response
GO:0008285
P:negative regulation of cell proliferation
GO:0055114
P:oxidation reduction
GO:0042554
P:superoxide anion generation
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References (17)[1] “Identification of renox, an NAD(P)H oxidase in kidney.” Geiszt M.et.al. 10869423 [2] “Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.” Cheng G.et.al. 11376945 [3] “A novel superoxide-producing NAD(P)H oxidase in kidney.” Shiose A.et.al. 11032835 [4] “NADPH oxidase-dependent acid production in airway epithelial cells.” Schwarzer C.et.al. 15210697 [5] “Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.” Goyal P.et.al. 15721269 [6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [7] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells.” Vaquero E.C.et.al. 15155719 [10] “Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.” Park H.S.et.al. 15356101 [11] “The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.” Mahadev K.et.al. 14966267 [12] “NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.” Pedruzzi E.et.al. 15572675 [13] “Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma.” Maranchie J.K.et.al. 16230378 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS 61: ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV 121: AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY 181: AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP 241: EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY 301: RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP 361: TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES 421: LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH 481: NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK 541: TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS