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Accession Number: | Q9Y5S8 |
Protein Name: | NOX1 aka NOH1 aka Mox1 |
Length: | 564 |
Molecular Weight: | 64871.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | electron |
Cross database links:
RefSeq: | NP_008983.2 NP_039249.1 |
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Entrez Gene ID: | 27035 |
Pfam: | PF08022 PF01794 PF08030 |
OMIM: |
300225 gene |
KEGG: | hsa:27035 |
Gene Ontology
GO:0005769
C:early endosome
GO:0043020
C:NADPH oxidase complex
GO:0009055
F:electron carrier activity
GO:0050660
F:FAD binding
GO:0005506
F:iron ion binding
GO:0050661
F:NADP or NADPH binding
GO:0048365
F:Rac GTPase binding
GO:0016175
F:superoxide-generating NADPH oxidase activity
GO:0030171
F:voltage-gated proton channel activity
GO:0001525
P:angiogenesis
GO:0016477
P:cell migration
GO:0022900
P:electron transport chain
GO:0006746
P:FADH2 metabolic process
GO:0042743
P:hydrogen peroxide metabolic process
GO:0006954
P:inflammatory response
GO:0051454
P:intracellular pH elevation
GO:0006739
P:NADP metabolic process
GO:0045726
P:positive regulation of integrin biosyntheti...
GO:0048661
P:positive regulation of smooth muscle cell p...
GO:0010575
P:positive regulation vascular endothelial gr...
GO:0015992
P:proton transport
GO:0008217
P:regulation of blood pressure
GO:0045730
P:respiratory burst
GO:0009268
P:response to pH
GO:0007165
P:signal transduction
GO:0042554
P:superoxide anion generation
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References (8)[1] “Cell transformation by the superoxide-generating oxidase Mox1.” Suh Y.-A.et.al. 10485709 [2] “A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1.” Banfi B.et.al. 10615049 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MGNWVVNHWF SVLFLVVWLG LNVFLFVDAF LKYEKADKYY YTRKILGSTL ACARASALCL 61: NFNSTLILLP VCRNLLSFLR GTCSFCSRTL RKQLDHNLTF HKLVAYMICL HTAIHIIAHL 121: FNFDCYSRSR QATDGSLASI LSSLSHDEKK GGSWLNPIQS RNTTVEYVTF TSIAGLTGVI 181: MTIALILMVT SATEFIRRSY FEVFWYTHHL FIFYILGLGI HGIGGIVRGQ TEESMNESHP 241: RKCAESFEMW DDRDSHCRRP KFEGHPPESW KWILAPVILY ICERILRFYR SQQKVVITKV 301: VMHPSKVLEL QMNKRGFSME VGQYIFVNCP SISLLEWHPF TLTSAPEEDF FSIHIRAAGD 361: WTENLIRAFE QQYSPIPRIE VDGPFGTASE DVFQYEVAVL VGAGIGVTPF ASILKSIWYK 421: FQCADHNLKT KKIYFYWICR ETGAFSWFNN LLTSLEQEME ELGKVGFLNY RLFLTGWDSN 481: IVGHAALNFD KATDIVTGLK QKTSFGRPMW DNEFSTIATS HPKSVVGVFL CGPRTLAKSL 541: RKCCHRYSSL DPRKVQFYFN KENF