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5.B.1.1.4 Mitogenic NADPH oxidase 3, Nox3 (Cheng et al., 2001). Critical for formation of otoconia, mineral crystals in the inner ear; mutants are defective for motion and gravity sensing (Paffenholz et al., 2004).
Accession Number:	Q9HBY0
Protein Name:	Nox3
Length:	568
Molecular Weight:	64935.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	electron

RefSeq:	NP_056533.1
Entrez Gene ID:	50508
Pfam:	PF08022 PF01794 PF08030
OMIM:	607105 gene
KEGG:	hsa:50508
Gene Ontology GO:0009055 F:electron carrier activity GO:0050660 F:FAD binding GO:0005506 F:iron ion binding GO:0055114 P:oxidation reduction
References (5) [1] “Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.” Cheng G.et.al. 11376945 [2] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [3] “NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells.” Kikuchi H.et.al. 10974555 [4] “Nox3 regulation by NOXO1, p47phox, and p67phox.” Cheng G.et.al. 15181005 [5] “The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.” Ueno N.et.al. 15824103

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MMGCWILNEG LSTILVLSWL GINFYLFIDT FYWYEEEESF HYTRVILGST LAWARASALC 
61:	LNFNCMLILI PVSRNLISFI RGTSICCRGP WRRQLDKNLR FHKLVAYGIA VNATIHIVAH 
121:	FFNLERYHWS QSEEAQGLLA ALSKLGNTPN ESYLNPVRTF PTNTTTELLR TIAGVTGLVI 
181:	SLALVLIMTS STEFIRQASY ELFWYTHHVF IVFFLSLAIH GTGRIVRGQT QDSLSLHNIT 
241:	FCRDRYAEWQ TVAQCPVPQF SGKEPSAWKW ILGPVVLYAC ERIIRFWRFQ QEVVITKVVS 
301:	HPSGVLELHM KKRGFKMAPG QYILVQCPAI SSLEWHPFTL TSAPQEDFFS VHIRAAGDWT 
361:	AALLEAFGAE GQALQEPWSL PRLAVDGPFG TALTDVFHYP VCVCVAAGIG VTPFAALLKS 
421:	IWYKCSEAQT PLKLSKVYFY WICRDARAFE WFADLLLSLE TRMSEQGKTH FLSYHIFLTG 
481:	WDENQALHIA LHWDENTDVI TGLKQKTFYG RPNWNNEFKQ IAYNHPSSSI GVFFCGPKAL 
541:	SRTLQKMCHL YSSADPRGVH FYYNKESF

5.B.1.1.4
Mitogenic NADPH oxidase 3, Nox3 (Cheng et al., 2001). Critical for formation of otoconia, mineral crystals in the inner ear; mutants are defective for motion and gravity sensing (Paffenholz et al., 2004).

Cross database links:

Gene Ontology

References (5)

External Searches:

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5.B.1.1.4Mitogenic NADPH oxidase 3, Nox3 (Cheng et al., 2001). Critical for formation of otoconia, mineral crystals in the inner ear; mutants are defective for motion and gravity sensing (Paffenholz et al., 2004).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

5.B.1.1.4
Mitogenic NADPH oxidase 3, Nox3 (Cheng et al., 2001). Critical for formation of otoconia, mineral crystals in the inner ear; mutants are defective for motion and gravity sensing (Paffenholz et al., 2004).