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|---|---|
| Accession Number: | Q9NRD9 |
| Protein Name: | Duox1 aka Large Nox1 |
| Length: | 1551 |
| Molecular Weight: | 177235.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 6 |
| Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
| Substrate | electron |
Cross database links:
| RefSeq: | NP_059130.2 NP_787954.1 |
|---|---|
| Entrez Gene ID: | 53905 |
| Pfam: | PF03098 PF00036 PF08022 PF01794 PF08030 |
| OMIM: |
606758 gene |
| KEGG: | hsa:53905 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0016021
C:integral to membrane
GO:0005509
F:calcium ion binding
GO:0009055
F:electron carrier activity
GO:0050660
F:FAD binding
GO:0020037
F:heme binding
GO:0016174
F:NAD(P)H oxidase activity
GO:0050661
F:NADP or NADPH binding
GO:0004601
F:peroxidase activity
GO:0042335
P:cuticle development
GO:0019221
P:cytokine-mediated signaling pathway
GO:0042446
P:hormone biosynthetic process
GO:0050665
P:hydrogen peroxide biosynthetic process
GO:0042744
P:hydrogen peroxide catabolic process
GO:0055114
P:oxidation reduction
GO:0051591
P:response to cAMP
GO:0042554
P:superoxide anion generation
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References (11)[1] “Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.” De Deken X.et.al. 10806195 [2] “Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.” Edens W.A.et.al. 11514595 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “Analysis of the DNA sequence and duplication history of human chromosome 15.” Zody M.C.et.al. 16572171 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.” De Deken X.et.al. 11822874 [7] “Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.” Geiszt M.et.al. 12824283 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGFCLALAWT LLVGAWTPLG AQNPISWEVQ RFDGWYNNLM EHRWGSKGSR LQRLVPASYA 61: DGVYQPLGEP HLPNPRDLSN TISRGPAGLA SLRNRTVLGV FFGYHVLSDL VSVETPGCPA 121: EFLNIRIPPG DPMFDPDQRG DVVLPFQRSR WDPETGRSPS NPRDPANQVT GWLDGSAIYG 181: SSHSWSDALR SFSRGQLASG PDPAFPRDSQ NPLLMWAAPD PATGQNGPRG LYAFGAERGN 241: REPFLQALGL LWFRYHNLWA QRLARQHPDW EDEELFQHAR KRVIATYQNI AVYEWLPSFL 301: QKTLPEYTGY RPFLDPSISS EFVAASEQFL STMVPPGVYM RNASCHFQGV INRNSSVSRA 361: LRVCNSYWSR EHPSLQSAED VDALLLGMAS QIAEREDHVL VEDVRDFWPG PLKFSRTDHL 421: ASCLQRGRDL GLPSYTKARA ALGLSPITRW QDINPALSRS NDTVLEATAA LYNQDLSWLE 481: LLPGGLLESH RDPGPLFSTI VLEQFVRLRD GDRYWFENTR NGLFSKKEIE EIRNTTLQDV 541: LVAVINIDPS ALQPNVFVWH KGDPCPQPRQ LSTEGLPACA PSVVRDYFEG SGFGFGVTIG 601: TLCCFPLVSL LSAWIVARLR MRNFKRLQGQ DRQSIVSEKL VGGMEALEWQ GHKEPCRPVL 661: VYLQPGQIRV VDGRLTVLRT IQLQPPQKVN FVLSSNRGRR TLLLKIPKEY DLVLLFNLEE 721: ERQALVENLR GALKESGLSI QEWELREQEL MRAAVTREQR RHLLETFFRH LFSQVLDINQ 781: ADAGTLPLDS SQKVREALTC ELSRAEFAES LGLKPQDMFV ESMFSLADKD GNGYLSFREF 841: LDILVVFMKG SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLAEVV 901: ESMFRESGFQ DKEELTWEDF HFMLRDHNSE LRFTQLCVKG VEVPEVIKDL CRRASYISQD 961: MICPSPRVSA RCSRSDIETE LTPQRLQCPM DTDPPQEIRR RFGKKVTSFQ PLLFTEAHRE 1021: KFQRSCLHQT VQQFKRFIEN YRRHIGCVAV FYAIAGGLFL ERAYYYAFAA HHTGITDTTR 1081: VGIILSRGTA ASISFMFSYI LLTMCRNLIT FLRETFLNRY VPFDAAVDFH RLIASTAIVL 1141: TVLHSVGHVV NVYLFSISPL SVLSCLFPGL FHDDGSELPQ KYYWWFFQTV PGLTGVVLLL 1201: ILAIMYVFAS HHFRRRSFRG FWLTHHLYIL LYVLLIIHGS FALIQLPRFH IFFLVPAIIY 1261: GGDKLVSLSR KKVEISVVKA ELLPSGVTHL RFQRPQGFEY KSGQWVRIAC LALGTTEYHP 1321: FTLTSAPHED TLSLHIRAAG PWTTRLREIY SAPTGDRCAR YPKLYLDGPF GEGHQEWHKF 1381: EVSVLVGGGI GVTPFASILK DLVFKSSVSC QVFCKKIYFI WVTRTQRQFE WLADIIREVE 1441: ENDHQDLVSV HIYITQLAEK FDLRTTMLYI CERHFQKVLN RSLFTGLRSI THFGRPPFEP 1501: FFNSLQEVHP QVRKIGVFSC GPPGMTKNVE KACQLINRQD RTHFSHHYEN F