| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
5.B.2.1.1 | Cytochrome b561 with an N-terminal cellobiose dehydrogenase (CDH)-like domain and a C-terminal cytb561 - FRRS1-like domain, both containing heme binding sites (Bérczi and Zimányi 2014). | Eukaryota |
Metazoa, Chordata | Cytb561 of Bos taurus (P10897) |
|
5.B.2.1.2 | Tumor suppressor (Tsp10 pending protein) | Eukaryota |
Metazoa, Chordata | Tsp10 of Mus musculus (NP_062694) |
|
5.B.2.1.3 | Duodenyl cytochrome b ferrireductase, Dcytb. Duodenyl L-Ascorbate (in):Fe3+ iron chelate (out) oxidoreduclase. Present in duodenal enterocyte brush boarder membranes (isoform 1); reduces dietary Fe3+ to Fe2+ to facilitate its transport into the mucosal cell. Binds two hemes non-covalently. Induced by iron deficiency. Also expressed in erythrocytes and respiratory epithelia (Lane and Lawen, 2009). | Eukaryota |
Metazoa, Chordata | Duodenyl cytochrome b reductase of Homo sapiens (Q53TN4) |
|
5.B.2.1.4 | Secretory vesicle-specific (chromafin granule) cytochrome b561 (isoform 2) | Eukaryota |
Metazoa, Chordata | Cytochrome b561 of Homo sapiens (P49447) |
|
5.B.2.1.5 | The Lysosomal ascorbate:ferric chelate oxidoreductase, Cytochrome b561 (isoform 3). | Eukaryota |
Metazoa, Chordata | Lysosomal cytochrome b561 of Homo sapiens (Q6P1H1) |
|
5.B.2.1.6 | Ascorbate-specific transmembrane electron transporter 1 (Cytochrome b561-1; Zmb561; ZCYB) of 236 aas and 6 TMSs. It is a tonoplast ascorbate-dependent monodehydroascorbate reductase (Gradogna et al. 2023). It may traslocate H+ across the membrane (Bérczi et al. 2023). | Eukaryota |
Viridiplantae, Streptophyta | ZCYB of Zea mays |
|
5.B.2.1.7 | Cytochrome b561 ferric reductase (Glanfield et al. 2010). | Eukaryota |
Metazoa, Platyhelminthes | Cyt b561 of Schistosoma japonicum |
|
5.B.2.1.8 | Transmembrane ascorbate:ferrireductase 2, AcyB or Cyb-1 of 230 aas and 6 TMSs. Also called cytochrome b561-1, ArtB561-2. | Eukaryota |
Viridiplantae, Streptophyta | AcyB of Arabidopsis thaliana |
|
5.B.2.2.1 | Ferric chelate reductase | Eukaryota |
Viridiplantae, Streptophyta | Ferric chelate reductase of Medicago truncatula |
|
5.B.2.2.2 | Cytochrome b561 ferric reductase with N-terminal DOMON-related domain (for heme or sugar binding). | Eukaryota |
Viridiplantae, Streptophyta | Ferric reductase of Arabidopsis thaliana |
|
5.B.2.2.3 | Ferric-chelate reductase 1. Involved in neurotransmitter synthesis and dietary iron uptake. (Picco et al. 2014). | Eukaryota |
Metazoa, Arthropoda | Ferric-chelate reductase 1 homologue of Drosophila melanogaster |
|
5.B.2.2.4 | Eukaryota |
Rhodophyta | Ctr fusion protein of Galdieria sulphuraria | |
|
5.B.2.2.5 | Uncharacterized protein of 535 aas and 5 C-terminal TMSs with an N-terminal DOMON domain and a C-terminal cytochrome b561 domain. | Eukaryota |
Viridiplantae, Chlorophyta | UP of Chlamydomonas reinhardtii |
|
5.B.2.2.6 | DOMON domain-containing protein FRRS1L precursor of 293 aas and 2 TMSs, one N-terminal and one C-terminal. Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities (Stewart et al. 2019). Alternative splicing of the flip/flop cassette and TARP auxiliary subunits engage in a privileged relationship that fine-tunes AMPA receptor gating (Perozzo et al. 2023). | Eukaryota |
Metazoa, Chordata | FRRS1L of Mus musculus |
|
5.B.2.2.7 | Cytochrome b561 and DOMON domain-containing protein, At4g12980, of 394 aas and 5 C-terminal TMSs. It may act as a catecholamine-responsive trans-membrane electron transporter (Verelst and Asard 2004). Tonoplast cytochrome b561 is a transmembrane ascorbate-dependent monodehydroascorbate reductase with two heme b groups bound non-covalently. It may be involved in catecholamine biochemistry in plants. It may catalyze transmembrane proton transport (Bérczi et al. 2023). | Eukaryota |
Viridiplantae, Streptophyta | Cyt b 561 of Arabidopsis thaliana |
|
5.B.2.3.1 | Uncharacterized protein of 403 aas and 6 TMSs in a 1 (N-termina) plus 5 TMS arrangement. | Eukaryota |
Fungi, Ascomycota | UP of Setosphaeria turcica (Northern leaf blight fungus) (Exserohilum turcicum) |
|
5.B.2.3.2 | Uncharacterized protein with an N-terminal TMS followed by a heme binding cytochrome domain of fungal cellubiose dehydrogenases and a C-terminal Cytochrome b-561 / ferric reductase 5 TMS transmembrane domain of 453 aas. | Eukaryota |
Fungi, Ascomycota | UP of Hypocrea virens (Gliocladium virens) (Trichoderma virens) |
|
5.B.2.3.3 | Uncharacterized putative cellobiose dehydrogenase of 476 aas and 6 (1 + 5) TMSs. These 5 TMSs may be homologous to those of the CBP family (9.B.306), but homology has not been established. | Eukaryota |
Fungi, Ascomycota | UP of Ophiocordyceps sinensis |
|
5.B.2.3.4 | Uncharacterized protein of 563 aas and 6 TMSs in a 1 + 300 residues, largely hydrophilic + 5 TMSs. This protein is homologous to the proteins in the family with TC# 9.B.57.1.1 showing extensive sequence similarity. The latter protein is the Mtp1 protein, essential for conidiation and conidial germination, of 520 aas and 12 TMSs (Lu et al. 2008). It has an N-terminal Cytb561 domain and a Ytp1 C-terminal domain. | Eukaryota |
Fungi, Ascomycota | UP of Neurospora crassa |
|
5.B.2.3.5 | Uncharacterized protein of 272 aas and 6 TMSs | Eukaryota |
Viridiplantae, Streptophyta | UP of Glycine soja |