Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


5.B.6.1.1
TSAP6 (dudulin-2 isoform B; Dudulin-2, pHyde; AHMIO2; STMP3; ) The dominant ferrireductase (metaloreductase) of the human erythroid transferrin cycle (Sendamarai et al. 2008). Also called six transmembrane epithelial antigen of protein-3 (Steap3) and tumor suppressor-activated pathway protein-6 (TSAP6). Consists primarily of a YedZ domain (9.B.43). STEAP3 affects ovarian cancer progression by regulating ferroptosis through the p53/SLC7A11 pathway (Han et al. 2024).

Accession Number:Q658P3
Protein Name:Metalloreductase STEAP3
Length:488
Molecular Weight:54601.00
Species: [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate electron

Cross database links:

DIP: DIP-46107N
RefSeq: NP_001008410.1    NP_060704.2    NP_861452.2    NP_878919.2   
Entrez Gene ID: 286148    55240   
Pfam: PF03807    PF01794   
OMIM: 609671  gene
KEGG: hsa:55240   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005771 C:multivesicular body
GO:0009055 F:electron carrier activity
GO:0050660 F:FAD binding
GO:0005506 F:iron ion binding
GO:0006915 P:apoptosis
GO:0007049 P:cell cycle
GO:0006826 P:iron ion transport
GO:0055114 P:oxidation reduction
GO:0009306 P:protein secretion

References (12)

[1] “The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.”  Passer B.J.et.al.   12606722
[2] “Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer.”  Korkmaz C.G.et.al.   15897894
[3] “Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde.”  Steiner M.S.et.al.   10969787
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Human pHyde is not a classical tumor suppressor gene in prostate cancer.”  Porkka K.P.et.al.   12866033
[9] “TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.”  Amzallag N.et.al.   15319436
[10] “Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition.”  Coulouarn C.et.al.   15885357
[11] “Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.”  Ohgami R.S.et.al.   16227996
[12] “The regulation of exosome secretion: a novel function of the p53 protein.”  Yu X.et.al.   16651434
Structure:
2VNS   2VQ3     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS GFKVVVGSRN 
61:	PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLSDQLAGKI LVDVSNPTEQ 
121:	EHLQHRESNA EYLASLFPTC TVVKAFNVIS AWTLQAGPRD GNRQVPICGD QPEAKRAVSE 
181:	MALAMGFMPV DMGSLASAWE VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV 
241:	QESQNKFFKL PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ 
301:	HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV EEEVWRMEIY 
361:	LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF VALVLSTLHT LTYGWTRAFE 
421:	ESRYKFYLPP TFTLTLLVPC VVILAKALFL LPCISRRLAR IRRGWEREST IKFTLPTDHA 
481:	LAEKTSHV