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5.B.6.1.2
Metalloreductase STEAP2 or STAMP1 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer; PUMPCn) Six-transmembrane epithelial antigen of prostate 2) (6TMS protein of prostate 1). Membrane cholesterol modulates the STEAP2 conformation during intracellular trafficking, leading to a broad subcellular distribution (Hasegawa et al. 2018). The molecular mechanism and function of STEAPs in the occurrence and development of different cancers have been reviewed (Chen et al. 2021).

Accession Number:Q8NFT2
Protein Name:Metalloreductase STEAP2
Length:490
Molecular Weight:56056.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 261729   
Pfam: PF03807    PF01794   
KEGG: hsa:261729   

Gene Ontology

GO:0005829 C:cytosol
GO:0005769 C:early endosome
GO:0010008 C:endosome membrane
GO:0030173 C:integral to Golgi membrane
GO:0005886 C:plasma membrane
GO:0030140 C:trans-Golgi network transport vesicle
GO:0042598 C:vesicular fraction
GO:0009055 F:electron carrier activity
GO:0050660 F:flavin adenine dinucleotide binding
GO:0005506 F:iron ion binding
GO:0000166 F:nucleotide binding
GO:0016491 F:oxidoreductase activity
GO:0005215 F:transporter activity
GO:0022900 P:electron transport chain
GO:0006897 P:endocytosis
GO:0006893 P:Golgi to plasma membrane transport
GO:0006811 P:ion transport
GO:0055072 P:iron ion homeostasis
GO:0045055 P:regulated secretory pathway
GO:0009725 P:response to hormone stimulus

References (6)

[1] “Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer.”  Korkmaz K.S.et.al.   12095985
[2] “Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.”  Porkka K.P.et.al.   12429817
[3] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[4] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[5] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[6] “The Steap proteins are metalloreductases.”  Ohgami R.S.et.al.   16609065

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS 
61:	RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM 
121:	RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE 
181:	LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA 
241:	RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ 
301:	CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY 
361:	ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE 
421:	EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP 
481:	HVSPERVTVM