TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.104.1.1









5'-Monophosphate-activated protein kinase (AMPK, PRKAA, AMPK2) of 552 aas.  See family description for detais of its regulation of transport. 

Eukaryota
Metazoa
AMPK of Homo sapiens
8.A.104.1.2









Camk, Camkl, AMPK protein kinase of 688 aas.

Eukaryota
Oomycetes
AMPK of Plasmopara halstedii
8.A.104.1.3









Serine/threonine-protein kinase SIK3 isoform X2of 1284 aas.

Eukaryota
Metazoa
SIK3 of Labrus bergylta
8.A.104.1.4









Protein kinase C-β, PRKCB or PKCB or PRKCB1, of 671 aas and 0 or 1 TMSs.  It participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. It also phosphorylates SLC2A1/GLUT1, promoting glucose uptake (Lee et al. 2015). It may also play a role in Meniere's disease (Lopez-Escamez et al. 2018).

Eukaryota
Metazoa
PRKCB of Homo sapiens
8.A.104.1.5









Salt Overly Sensitive-2 (SOS2) of 446 aas, possibly with 2 TMSs, but none at its N-terminus; a protein kinase.  The salt stress-induced SALT-OVERLY-SENSITIVE (SOS) pathway in Arabidopsis thaliana involves the perception of a calcium signal by the SOS3 and SOS3-like CALCIUM-BINDING PROTEIN8 (SCaBP8; 5.b.1.1.8) calcium sensors, which then interact with and activate the SOS2 protein kinase, forming a complex at the plasma membrane that activates the SOS1 Na⁺/H⁺ exchanger (2.A.36.7.6) (Lin et al. 2014Lin et al. 2014).

Eukaryota
Viridiplantae
SOS2 of Arabidopsis thaliana (Mouse-ear cress)
8.A.104.1.6









Protein kinase domain containing protein of 886 aas with 2 or 3 N-terminal TMSs.  Reveals homology of members of this family with 1.A.87.2.1, 9.B.15.1.1 and 9.B.45.1.3. all probably containing eukaryotic-type protein kinase domains.  The N-terminal 130 aas are homologous to residues 111 - 243 of 9.A.54.3.1, an LMBR1-like protein.

Eukaryota
Perkinsida
PK domain protein of Perkinsus marinus
8.A.104.1.7









SpdA of 270 aas and 4 putative N-terminal TMSs.  SpdA and SpdB (TC#9.B.106.1.3) are encoded on an 11-kbp multicopy plasmid, pSN22, isolated from Streptomyces nigrifaciens SN22. Both are homologous to DUF2637 domain-containing proteins, and both have 4 N-terminal TMSs. This plasmid is self-transmissible (conjugative), is maintained stably in S. lividans, and forms pocks in a wide range of Streptomyces strains.  SpdA and SpdB are involved in pock formation (Kataoka et al. 1991). SpdA may function  in intramycelial plasmid transfer (Mendes et al. 2000). SpdA (this entry) has a 4 TMS 100 residue sequence homologous to the 4 TMSs in TC# 8.A.104.1.8, but lacks the protein kinase domain of the latter. This 4 TMS sequence is not found in other members of this family.

Bacteria
Actinobacteria
SpdA pf Streptomyces sp. SPB74 (B5G9R1)
8.A.104.1.8









Serine/Threonine protein kinase of 741 aas, 4 N-terminal TMSs, and possibly 2 or 3 central TMSs The kinase domain is like those of 9.A.15.1.1 and 9.B.45.1.3.

Bacteria
Actinobacteria
S/T protein kinase of Amycolatopsis mediterranei (D8HIS0)
8.A.104.1.9









Serine/threonine-protein kinase/endoribonuclease, IRE1 or ERN1, of 977 aas and 2 TMSs, one N-terminal and one centrally located in the protein. It acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (Yoshida et al. 2001; Ali et al. 2011). IRE1 acts to reposition lysosomes and protects cells from stress. Blos1 regulation by IRE1 promotes late endosome-mediated microautophagy of protein aggregates and protects cells from their cytotoxic effects   (Bae et al. 2019). The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes (Tran et al. 2021).

Eukaryota
Metazoa
IRE1 of Homo sapiens
8.A.104.1.10









RAC-α ser/thr kinase, Akt1 (PKB, RAC) of 480 aas. AKT1, AKT2 amd ALT3 regulate glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (Kane et al. 2002). The AKT1 isoform has a more specific role in cell motility and proliferation (Enomoto et al. 2005).

Eukaryota
Metazoa
Akt1 of Homo sapiens
8.A.104.1.11









Calcium/calmodulin-dependent protein kinase type II, subunit alpha, CAMKIIA, of 478 aas and 0 TMSs. It regulates ion channel activities (see TC#s 1.A.1.20.6 and 1.A.17.1.1) (Ko et al. 2020). In addition, it functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. It is a member of the NMDAR signaling complex in excitatory synapses and regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission, and it regulates dendritic spine development (Stephenson et al. 2017).

Eukaryota
Opisthokonta
CAMKIIA of Homo sapiens
8.A.104.1.12









Calcium/calmodulin-dependent protein kinase type II, subunit gamma, CAMK2G, of 558 aas and 1 - 3 TMSs. It  functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and slow twitch muscle (Rose et al. 2006). In fast-twitch muscle, it participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (TC# 8.A.28.1.3) (Proietti Onori et al. 2018).

 

Eukaryota
Opisthokonta
CAMK2G of Homo sapiens
8.A.104.1.13









Protein kiinase of 554 aas and 3 TMSs. Unusual features and localization of the membrane kinome, including 10 membrane associated protein kinases of Trypanosoma brucei have been described and discussed (Jensen et al. 2021).

Eukaryota
Discoba
Protein kinase of Trypanosoma brucei brucei