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8.A.104.1.9
Serine/threonine-protein kinase/endoribonuclease, IRE1 or ERN1, of 977 aas and 2 TMSs, one N-terminal and one centrally located in the protein. It acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (Yoshida et al. 2001; Ali et al. 2011). IRE1 acts to reposition lysosomes and protects cells from stress. Blos1 regulation by IRE1 promotes late endosome-mediated microautophagy of protein aggregates and protects cells from their cytotoxic effects   (Bae et al. 2019). The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes (Tran et al. 2021).

Accession Number:O75460
Protein Name:Serine/threonine-protein kinase/endoribonuclease IRE1
Length:977
Molecular Weight:109735.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
2HZ6   3P23   4U6R   4YZ9   4YZC   4YZD   4Z7G   4Z7H   5HGI   6HV0   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 
61:	VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 
121:	KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 
181:	DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 
241:	MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 
301:	HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN KLNYLRNYWL 
361:	LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVINLVDQT SENAPTTVSR 
421:	DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 
481:	KELEKIQLLQ QQQQQLPFHP PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 
541:	SSASKAGSSP SLEQDDGDEE TSVVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 
601:	ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 
661:	LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 
721:	GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 
781:	RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 
841:	FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 
901:	LRAMRNKKHH YRELPAEVRE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 
961:	YFHEPPEPQP PVTPDAL