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8.A.111.1.1
Store operated calcium entry (SOCE)-associated regulatory factor, SARAF, ia of 339 aas with 2 or 3 TMSs.  Overexpression of SARAF in the heart prevents cardiac hypertrophy, probably through suppressing the upregulation of STIM1/Orai1 (Dai et al. 2018). TMEM66 attenuates neointimal hyperplasia after carotid artery injury by store operated calcium entry (SOCE) inactivation. It confers vascular protection against balloon injury (Yang et al. 2019).

Accession Number:Q96BY9
Protein Name:Store-operated calcium entry-associated regulatory factor
Length:339
Molecular Weight:36975.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
6O2U   6O2V   6O2W     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAACGPGAA GYCLLLGLHL FLLTAGPALG WNDPDRMLLR DVKALTLHYD RYTTSRRLDP 
61:	IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS 
121:	EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWSSADS CNMSGLITIV 
181:	VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH 
241:	GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP 
301:	GTWNRAYSPL HGGSGSYSVC SNSDTKTRTA SGYGGTRRR