TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.133.1.2
Siah-2 of 324 aas.  Seven in absentia homologue-2 (Siah-2) is a host protein that can act as does Siah-1, but with different protein specificities. It mediates the ubiquitination of proteins and is known for its interaction with them to alter their stabilities as affect several cell functions (Malz et al. 2012).

Accession Number:O43255
Protein Name:E3 ubiquitin-protein ligase SIAH2
Length:324
Molecular Weight:34615.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

Cross database links:

Structure:
5H9M     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MSRPSSTGPS ANKPCSKQPP PQPQHTPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG 
61:	GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP 
121:	SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS 
181:	LEAVMSHLMH AHKSITTLQG EDIVFLATDI NLPGAVDWVM MQSCFGHHFM LVLEKQEKYE 
241:	GHQQFFAIVL LIGTRKQAEN FAYRLELNGN RRRLTWEATP RSIHDGVAAA IMNSDCLVFD 
301:	TAIAHLFADN GNLGINVTIS TCCP