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8.A.177.1.8
Tumer necrosis factor, TNF, of 233 aas with a very hydrophobic TMS near the N-terminus of the protein. A cyclic peptide, solnatide, of 17 aas, modified from TNF (CGQRETPEGAEAKPWYC), residues 177 - 195) activates ENaC (TC# 1.A.6.1.1) (Madaio et al. 2019; Martin-Malpartida et al. 2022).

Accession Number:UQL51144.1
Protein Name:UQL51144.1 TNF [Homo sapiens]
Length:234
Molecular Weight:
Species:Homo sapiens [9606]
Number of TMSs:1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR 
61:	EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR 
121:	DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE 
181:	TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL