8.A.177.1.8 Tumer necrosis factor, TNF, of 233 aas with a very hydrophobic TMS near the N-terminus of the protein. A cyclic peptide, solnatide, of 17 aas, modified from TNF (CGQRETPEGAEAKPWYC), residues 177 - 195) activates ENaC (TC# 1.A.6.1.1) (Madaio et al. 2019; Martin-Malpartida et al. 2022).
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Accession Number: | UQL51144.1 |
Protein Name: | UQL51144.1 TNF [Homo sapiens] |
Length: | 234 |
Molecular Weight: | |
Species: | Homo sapiens [9606] |
Number of TMSs: | 1 |
Substrate |
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1: MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR
61: EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR
121: DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE
181: TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL