| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.18.1.1 | Dihydropyridine-sensitive L-type, Ca2+ channel subunit, Cav2.2, α2δ subunit 1, CACNA2D1, NL2A, CCHL2A, MHS3 of 1103 aas and at least 2 TMSs, N- and C-terminal. An N-terminal region (the R-domain) is necessary and sufficient for Cav2.2 regulation (Song et al. 2015). This subunit is regulated at the transcriptional level by microRNA, MiR-183, which thereby regulates nociceptive basal and neuropathic pain (Peng et al. 2017). It is upregulated in the low hydraulic resistance channel (LHRC) along meridians (Song et al. 2021). The Ca2+ channel α2δ-1 auxiliary subunit plays a role in proliferation and migration of human glioblastoma cells (Fernández-Gallardo et al. 2022). | Eukaryota |
Metazoa, Chordata | CACNA2D1 of Homo sapiens (P54289) |
|
8.A.18.1.2 | Ca2+ channel, α2δ subunit 2, CACNA2D2 (Zhang et al. 2017). | Eukaryota |
Metazoa, Chordata | CACNA2D2 of Homo sapiens (Q9NY47) |
|
8.A.18.2.1 | Cachd domain-containing protein 1, Cachd1, of 1290 aas and 2 TMSs. Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain (Powell et al. 2024). This protein is 88% identical to the human homolog (TC# 8.A.18.2.2). | Eukaryota |
Metazoa, Chordata | Cachd1 of Danio rerio (Zebrafish) (Brachydanio rerio) |
|
8.A.18.2.2 | CACHD1 of 1274 aas and 2 TMSs. CACHD1 is structurally an α2δ-like protein that functionally increases CaV3 calcium current. CACHD1 increases the presence of CaV3.1 (TC# 1.A.1.11.12) at the cell surface, forms complexes with CaV3.1, and causes an increase in channel open probability. In hippocampal neurons, CACHD1 causes increases in neuronal firing, so CACHD1 modulates CaV3 activity (Cottrell et al. 2018). | Eukaryota |
Metazoa, Chordata | CACHD1 of Homo sapiens |
|
8.A.18.3.1 | Ca2+ channel, voltage-dependent, α2δ subunit 3, CACNA2D3 of 1091 aas and 2 - 4 TMSs (Baeza-Richer et al. 2015). | Eukaryota |
Metazoa, Chordata | CACNA2D3 of Homo sapiens (Q8IZS8) |
|
8.A.18.3.2 | Voltage-gated Ca2+ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018). The importance of the cache domains in α2δ proteins and the basis for their gabapentinoid selectivity has been discussed (Page et al. 2023). | Eukaryota |
Metazoa, Chordata | CACNA2D4 of Homo sapiens (Q8IZS9) |