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8.A.19.1.1
Na+ channel auxilliary subunit, TipE, of 452 aas and 2 TMSs. Modifies channel function and gating,  and plays a role in channel biogeneisis (Wang et al. 2013).

Accession Number:P48613
Protein Name:TipE aka CG1232
Length:452
Molecular Weight:50190.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_523920.1    NP_728952.1   
Entrez Gene ID: 38504   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-015133-MONOMER    DMEL-XXX-02:DMEL-XXX-02-015134-MONOMER   
KEGG: dme:Dmel_CG1232   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0017080 F:sodium channel regulator activity
GO:0005248 F:voltage-gated sodium channel activity
GO:0034605 P:cellular response to heat
GO:0045433 P:male courtship behavior, veined wing genera...
GO:0090072 P:positive regulation of sodium ion transport...
GO:0006814 P:sodium ion transport

References (4)

[1] “Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function.”  Feng G.et.al.   7553842
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDEQDKRTG KEKLLFYTTA FFILLGTFSL FAFLFLVPFV IEPAFTTIFM QFEEVPALCE 
61:	TYDTEIYYGA KNCSWSSCRE GCTKDIYTCT QIRVNYRLNL YNFTDEFNFT EYHINLKEAE 
121:	RILPPVKRTD RYERALRSDY EYDNLGGGTG LDIDLGAGRM EQLNFGDADG SNGYLIEDSE 
181:	DTRGLSASGT LISDERRPFD EISELNEGLM GNRSMYYYVG ARLFPNVKGC GYPPMLNCTI 
241:	WLKRYTKIGM KFPCYYSKVD PSLVISDLDY WQNTLNLVYS MAIPIPSFII SVIYLTYAYF 
301:	KIYNEDEETA PLDKNAEDMD IDDIDAVDDS DGAVLADNVA GSQIINMDST TNDSCLEGVL 
361:	PNGGPGMTAS ISQGGSVTTP GPYIAQSPAG SQMTPNSEIN SFGHQLKVQM ADELSRDSLE 
421:	NGAISTSNSV QGNLSKTMTT SISTPPGPTA AV