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8,A,194.  The Sorting Nexin (SNX) Family 

SNX1 and other sorting nexins are involved in several stages of intracellular trafficking. It interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (Cozier et al. 2002). It acts as a component of the retromer membrane-deforming SNX-BAR subcomplex (TC families 9.A.3 and 9.A 63). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) and can sense membrane curvature; it has in vitro vesicle-to-membrane remodeling activity (Bhatia et al. 2009, van Weering et al. 2012). It is also involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin, StxB. It plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (Cozier et al. 2002, Kim et al. 2010). SNX1 interacts  with SNX27 and regulates the heavy metal transporter Irt1 (TC# 2.A.5.1.2) (Chandra et al. 2022). Sorting nexins are also found in TC families 9.A.3 and 9.A.63.

 

 

 

 

 

References associated with 8.A.194 family:

Bhatia, V.K., K.L. Madsen, P.Y. Bolinger, A. Kunding, P. HedegÄrd, U. Gether, and D. Stamou. (2009). Amphipathic motifs in BAR domains are essential for membrane curvature sensing. EMBO. J. 28: 3303-3314. 19816406
Chandra, M., B.M. Collins, and L.P. Jackson. (2022). Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus. Adv Biol Regul 83: 100842. 34866035
Cozier, G.E., J. Carlton, A.H. McGregor, P.A. Gleeson, R.D. Teasdale, H. Mellor, and P.J. Cullen. (2002). The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J. Biol. Chem. 277: 48730-48736. 12198132
Ivanov, R., T. Brumbarova, A. Blum, A.M. Jantke, C. Fink-Straube, and P. Bauer. (2014). SORTING NEXIN1 is required for modulating the trafficking and stability of the Arabidopsis IRON-REGULATED TRANSPORTER1. Plant Cell 26: 1294-1307. 24596241
Kim, E., Y. Lee, H.J. Lee, J.S. Kim, B.S. Song, J.W. Huh, S.R. Lee, S.U. Kim, S.H. Kim, Y. Hong, I. Shim, and K.T. Chang. (2010). Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem. Biophys. Res. Commun. 403: 167-171. 21040701
van Weering, J.R., R.B. Sessions, C.J. Traer, D.P. Kloer, V.K. Bhatia, D. Stamou, S.R. Carlsson, J.H. Hurley, and P.J. Cullen. (2012). Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO. J. 31: 4466-4480. 23085988