TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.204.1.1









E-cadherin of 882 aas and probably 2 TMSs, one N-terminal and one near the C-terminus of the protein.  It shuffles between the plasma membrane and the nuclear membrane (Lessey et al. 2022).

Eukaryota
Metazoa, Chordata
CDH-1 of Homo sapiens
8.A.204.1.2









Cadherin-22 isoform X1 of 856 aas and probably two TMSs, one N-terminal and one near the C-terminus (residues 665 to 685).

Eukaryota
Metazoa, Chordata
CADH of Mauremys reevesii (Reeves's turtle)
8.A.204.1.3









Desmoglein-1 of 1050 aas and 2 TMSs, one N-terminal and one at residues 550 - 570. Epidermal stratification requires retromer-mediated desmoglein-1 recycling (Hegazy et al. 2022).

Eukaryota
Metazoa, Chordata
Desmoglein-1 of Equus asinus (ass)
8.A.204.1.4









Cadherin-like protein 26 of 825 aas with two TMSs, one N-terminal and one at residues 595 - 615.

Eukaryota
Metazoa, Chordata
CDH26 of Girardinichthys multiradiatus
8.A.204.1.5









Desmocollin-2, DSC2, of 901 aas with two TMSs, one N-terminal and the other at residue position 710.  It is a component of intercellular desmosome junctions and is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. It may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. It is alterred in amounts following acute kidney injury following Covid-19 infection (Paranjpe et al. 2023). In addition to other members of family 8.A.204, it contains a domain homologous to those in cadherin (TC# 9.A.14.6.4) and protocadherin (TC# 1.A.17.4.13). Cardiomyopathy-related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing (Pohl et al. 2023).

Eukaryota
Metazoa, Chordata
Desmocollin-2 of Homo sapiens
8.A.204.1.6









Cadherin-18, CDH18, isoform 1 preproprotein of 790 aas and 2 TMSs, one N-terminal and one at residues 620 - 645. Celiac disease (CD) is a complex immune disease that affects duodenal mucosa, and CDH18 is present in lower amounts in diseased people.

Eukaryota
Metazoa, Chordata
CDH18 of Homo sapiens
8.A.204.1.7









Desmoglein-3, Dsg3 (CDHF6) of 999 aas.  It is a omponent of intercellular desmosome junctions and is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.  Gold nanoclusters (AuNCs) conjugated with Dsg-3 antibodies form Au-Dsg-3 through a coupling reaction (Zhang et al. 2024).

Eukaryota
Metazoa, Chordata