8.A.205. The Tmem65 (Tmem65) Family
Tmem65 plays a role in cardiac development and function. and may regulate cardiac conduction and the function of the gap junction protein GJA1 (TC# 1.A.24.1.1). It may also contribute to the stability and proper localization of GJA1 in the cardiac intercalated disk, thereby regulating gap junction communication. It may also regulate mitochondrial respiration and mitochondrial DNA copy number maintenance (Nazli et al. 2017). It is critical for the structure and function of the intercalated discs in mouse hearts (Teng et al. 2022).