TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.21.3.1
Flotillin-1 (FLOT1) or Reggie 2 (Reg2) of 423 aas and 1 N-terminal TMS. Flotillin upregulation is necessary and sufficient to promote epithelial and mesenchymal cancer cell invasion and ECM degradation by controlling  endocytosis and delivery of the transmembrane protease, MT1-MMP or MMP14 (TC# 8.B.14.2.3) to the endolysosomal recycling compartment  (Planchon et al. 2018). Flotillin-2, a  paralog of Flotillin-1 (48% identity) (see TC# 8.A.21.3.2), serves the same or an overlapping function. Flotillin-1 interacts with and sustains the surface levels of the TRPV2 channel (Hu et al. 2021).

Accession Number:O75955
Protein Name:Flotillin-1
Length:427
Molecular Weight:47355.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG 
61:	VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI 
121:	YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE 
181:	AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL 
241:	QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA 
301:	EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK 
361:	LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN 
421:	HKPLRTA