8.A.215. The Plasmalemma Vesicle-associated Protein (PLVAP) Family
PLVAP proteins are endothelial cell-specific membrane proteins involved in the formation of the diaphragms that bridge endothelial fenestrae. They are also required for the formation of stomata of caveolae and transendothelial channels. They function in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. They play a specific role in embryonic development. Structural insights into PLVAP have been discussed, and implications for vascular endothelial diaphragms and fenestrae (Chang et al. 2023).