TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
8.A.216.1.1 | The Golgi SNAP receptor complex, member 1, GS28 or GOSR1, of 250 aas with one C-terminal TMS. It is involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. It may play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). It participates in docking and fusion stage of ER to cis-Golgi transport and plays important physiological roles in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. GS28 protects against neuronal cell death mediated in response to hydrogen peroxide (Lee et al. 2011). | Eukaryota |
Metazoa, Chordata | GS28 of Homo sapiens |
8.A.216.1.2 | Uncharacterized protein, BB560_004092, of 209 aas and 1 C-terminal TMS. | Eukaryota |
Fungi, Zoopagomycota | UP of Smittium megazygosporum |
8.A.216.1.3 | v-SNARE protein of 220 aas and 1 C-terminal TMS
| Eukaryota |
v-SNARE protein of Blastocystis sp. | |
8.A.216.1.4 | Golgi SNARE protein-like protein of 277 aas and 1 C-terminal TMS. | Eukaryota |
Euglenozoa | Snare protein of Leishmania braziliensis |
8.A.216.1.5 | Protein transport protein bos1 of 240 aas and 1 C-terminal TM | Eukaryota |
Fungi, Chytridiomycota | Bos1 of Chytriomyces hyalinus |
8.A.216.1.6 | Uncharacterized protein of 415 aas and possibly two TMSs at residues 140 - 170 and 360 - 390. It may be duplicated, but the C-terminal domain show the greatest sequence similarities with other members of this family. | Eukaryota |
Viridiplantae, Streptophyta | UP of Smallanthus sonchifolius |
8.A.216.1.7 | Gos1 of 223 aas with 1 C-terminal TMS. It is a Golgi SNAP receptor, complex member 1, and an anchor for type IV membrane proteins. It is a membrane phosphoprotein involved in ER to Golgi transport as part of the Golgi apparatus and plays a role in protein transport within the golgi. It interacts with SED5, YKT6 AND SFT1 (Dederer and Lemberg 2021). Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins (Gillingham et al. 2002; Siniossoglou and Pelham 2001).
| Eukaryota |
Fungi, Ascomycota | Gos1 of Saccharomyces cerevisiae |