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TCIDNameDomainKingdom/PhylumProtein(s)
8.A.217.1.1









The massive protein machine that regulates cell death/apoptosis, BIRC6 is a subunit of 4857 aas with one BIR domain.  The complex regulates several caspases (caspase3, caspase7 and caspase9 as well as Omi; see below), BIRC6, SMAC, several IAPs (inhibitors of apoptosis), and ACDR (Apoptosis Cell Death Regulator).

Eukaryota
 Metazoa, Chordata
Regulator of Cell Death and Apoptosis
BIRC6, 4857 aas, Q9NR09
Caspase3, CPP3, 277 aas, P42574
Caspase7, CPP7, 303 aas, P55210
Caspase9, CPP9, 416 aas, P55211
HTRA2 apoptosis serine protease, 458 aas, O43464
SMAC (Second Mitochondria-derived Activator of Caspases)
IAPs (Inhibitors of Apoptosis) - contain 1 - n baculoviral IAP repeats (BIRs)