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| Accession Number: | P35613 |
| Protein Name: | Basigin [Precursor] aka EMMPRIN aka 5F7 aka TCSF |
| Length: | 385 |
| Molecular Weight: | 42200.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Single-pass type I membrane protein2 |
| Substrate | |
Cross database links:
| RefSeq: | NP_001719.2 NP_940991.1 NP_940993.1 |
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| Entrez Gene ID: | 682 |
| OMIM: |
109480 gene 111380 phenotype |
| KEGG: | hsa:682 |
Gene Ontology
GO:0000139
C:Golgi membrane
GO:0016021
C:integral to membrane
GO:0042470
C:melanosome
GO:0015129
F:lactate transmembrane transporter activity
GO:0005537
F:mannose binding
GO:0005515
F:protein binding
GO:0007166
P:cell surface receptor linked signaling pathway
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References (22)[1] “Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.” Kasinrerk W.et.al. 1634773 [2] “The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen.” Miyauchi T.et.al. 1783610 [3] “The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.” Biswas C.et.al. 7812975 [4] “Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.” Guo H.et.al. 9767135 [5] “Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.” Ochrietor J.D.et.al. 12939332 [6] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.” Clark H.F.et.al. 12975309 [7] “The DNA sequence and biology of human chromosome 19.” Grimwood J.et.al. 15057824 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.” Zhang Z.et.al. 15340161 [10] “Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor.” Nabeshima K.et.al. 1846736 [11] “Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.” Muramatsu T.et.al. 12792908 [12] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [13] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [14] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [15] “junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.” Schreiner A.et.al. 17267690 [16] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.” Molina H.et.al. 17287340 [17] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [18] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [19] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [20] “Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.” Yu X.-L.et.al. 18430721 [21] “Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping.” Luo J.et.al. 19768682 [22] “The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues.” Spring F.A.et.al. 9130641
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| Structure: | |
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| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 61: QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 121: RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 181: DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 241: VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 301: CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 361: GSAPLKSSGQ HQNDKGKNVR QRNSS