8.A.23.1.10
Activated leukocyte cell adhesion molecule, ALCAM or CD166 antigen, of 583 aas and 2 TMSs, N- and C-terminal. It is expressed on and in the cell membranes of various cells. In the spinal cord dorsal horn (DH), the first gate for the sensory and pain transmission to the brain, ALCAM plays modulatory roles in the excitatory synaptic transmission and plasticity in the (rat) spinal DH (Park et al. 2017).
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| Accession Number: | Q13740 |
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| Protein Name: | CD166 antigen |
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| Length: | 583 |
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| Molecular Weight: | 65102.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK
61: PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN
121: VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL
181: EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF
241: DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL
301: TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR
361: NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM
421: TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN
481: VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA
541: LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA