8.A.23.1.11
Interleukin 1 receptor of 569 aas and 2 TMSs, N-terminal and near the middle of the protein. It is the receptor for IL1A, IL1B and IL1RN. After
binding to interleukin-1, it associates with the coreceptor IL1RAP to form
the high affinity interleukin-1 receptor complex which mediates
interleukin-1-dependent activation of NF-kappa-B, MAPK and other
pathways. Signaling involves the recruitment of adapter molecules such
as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of
the receptor/coreceptor subunits. It binds ligands with comparable affinity,
and binding of antagonist IL1RN prevents association with IL1RAP to
form a signaling complex (Slack et al. 2000).
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| Accession Number: | P14778 |
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| Protein Name: | Interleukin-1 receptor type 1 |
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| Length: | 569 |
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| Molecular Weight: | 65402.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD
61: DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL
121: CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR
181: LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL
241: GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE
301: IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK
361: IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG
421: YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ
481: DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV
541: QRRSPSSKHQ LLSPATKEKL QREAHVPLG